interface graph thumbnail
legend  pdf

structure nameTWIST1-TCF4-ALX4 COMPLEX ON SPECIFIC DNA
referenceMorgunova et al. Cell 187 692 2024
experimentX-ray (resolution=2.90, R-factor=0.223)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
multimeric complexes8osb_ABE
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRQVQN

Estimated binding specificities ?

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# IC=2.352 IC/col=0.336 n_of_columns=7 specificity:   
A |   4  10  81  63  22  24  42
C |   4  10   7  10  22  24  18
G |  81  13   4  13  22  24  18
T |   7  63   4  10  30  24  18
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RT--QTVAQTNA------   L                              +8osb_E    
                                             +--------1 
  RA----IAQTNA------   L                     !        +5ego_B    
                                         +---5 
  RT----VTKGNA--KA--   L                 !   !       +2lkx_A    
                                         !   +-------3 
  RT----NT--NA------   L           +-----6           +1b72_B    
                                   !     ! 
  ------NCICNARGRG--   L           !     !            +4xrm_B    
                           +-------7     +------------2 
  --RT--NT--NAIARG--   L   !       !                  +4cyc_B    
                           !       ! 
  RT----IAQCNAMG----   L --8       !             +----1b72_A    
                           !       +-------------4 
  RC----IAQCNAYC----   L   !                     +----3rkq_B    
                           ! 
  ------VTCCNAQA--RT   L   +--------------------------8g87_X    
                         

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updated Sun Jan 11 00:46:17 2026