8osb_E : 3D-footprint complex

structure name	TWIST1-TCF4-ALX4 COMPLEX ON SPECIFIC DNA
reference	Morgunova et al. Cell 187 692 2024
experiment	X-ray (resolution=2.90, R-factor=0.223)
structural superfamily	Homeodomain-like;
sequence family	Homeobox domain;
multimeric complexes	8osb_ABE
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 8osb_E interface=3,44,45,48,49, rnRttftsyqleelekvfqkthypdvyareqlamrtdltearvQVwfQNrrakwrkrerfgq
interface signature	RQVQN

Estimated binding specificities ?

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# IC=2.352 IC/col=0.336 n_of_columns=7

specificity:

A |   4  10  81  63  22  24  42
C |   4  10   7  10  22  24  18
G |  81  13   4  13  22  24  18
T |   7  63   4  10  30  24  18

scan!

Dendrogram of similar interfaces ?

matrix format

  
  RT--VTKGNA--KA--   L   +-----------------------------2lkx_A    
                         ! 
  RTQTVAQTNA------   L   !                            +8osb_E    
                       --5             +--------------1 
  ----NCICNARGRG--   L   !             !              +4xrm_B    
                         !     +-------3 
  RT--IAQCNAMG----   L   !     !       !          +----1b72_A    
                         +-----4       +----------2 
  RC--IAQCNAYC----   L         !                  +----3rkq_B    
                               ! 
  ----VTCCNAQA--RT   L         +-----------------------8g87_X

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updated Mon Aug 4 01:42:17 2025