interface graph thumbnail
legend  pdf

structure nameTWIST1-TCF4-ALX4 COMPLEX ON SPECIFIC DNA
referenceMorgunova et al. Cell 187 692 2024
experimentX-ray (resolution=2.90, R-factor=0.223)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
multimeric complexes8osb_ABE
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRQVQN

Estimated binding specificities ?

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# IC=2.352 IC/col=0.336 n_of_columns=7 specificity:   
A |   4  10  81  63  22  24  42
C |   4  10   7  10  22  24  18
G |  81  13   4  13  22  24  18
T |   7  63   4  10  30  24  18
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RTQTVAQTNA------   L                            +8osb_E    
                                   +--------------1 
  RT--VTKGNA--KA--   L       +-----3              +2lkx_A    
                             !     ! 
  ----NCICNARGRG--   L   +---4     +--------------4xrm_B    
                         !   ! 
  RT--IAQCNAMG----   L   !   !                +---1b72_A    
                       --5   +----------------2 
  RC--IAQCNAYC----   L   !                    +---3rkq_B    
                         ! 
  ----VTCCNAQA--RT   L   +------------------------8g87_X

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updated Sat Sep 14 11:28:35 2024