interface graph thumbnail
legend  pdf

structure nameTWIST1-TCF4-ALX4 COMPLEX ON SPECIFIC DNA
referenceMorgunova et al. Cell 187 692 2024
experimentX-ray (resolution=2.90, R-factor=0.223)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
multimeric complexes8osb_ABE
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRQVQN

Estimated binding specificities ?

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# IC=2.512 IC/col=0.359 n_of_columns=7 specificity:   
A |  18  24  27  13   4  63   4
C |  18  24  22  10   4  10  84
G |  18  24  25  10   4  13   4
T |  42  24  22  63  84  10   4
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RT--VTKGNA--KA--   L   +-----------------------------2lkx_A    
                         ! 
  RTQTVAQTNA------   L   !                            +8osb_E    
                         !             +--------------1 
  ----NCICNARGRG--   L --5        +----2              +4xrm_B    
                         !        !    ! 
  RT--IAQCNAMG----   L   !     +--3    +---------------1b72_A    
                         !     !  ! 
  RC--IAQCNAYC----   L   +-----4  +--------------------3rkq_B    
                               ! 
  ----VTCCNAQA--RT   L         +-----------------------8g87_X

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updated Wed Dec 18 18:57:33 2024