Estimated binding specificities ?

structure nameCRYSTAL STRUCTURE OF MYCOBACTERIUM SMEGMATIS TOPOISOMERASE I WITH SSDNA BOUND TO BOTH N- AND C-TERMINAL DOMAINS
(DNA topoisomerase 1)
referenceTse-Dinh et al. 'Nucleic 48 4448 2020
sourceMycobacterium smegmatis (strain ATCC 700084 / mc(2)155) / Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
experimentX-ray (resolution=3.11, R-factor=0.228)
structural superfamilyProkaryotic type I DNA topoisomerase;
sequence familyDNA topoisomerase; Toprim domain;
multimeric complexes6pcm_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
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# IC=6.157 IC/col=0.257 n_of_columns=24 specificity:   
A |  81  19  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24   0  96  24   0   0
C |   4  19  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24   0   0  24   0   0
G |   4  39  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  96   0  24   0   0
T |   7  19  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24  24   0   0  24  96  96
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ----RTHCDGRG--RT----RCRC--RCYTSTPT--WTKAPAKT--RTSTTG----------RTFTYTSTYGYASASA                +---6pcm_B    
                                                                                           +----1 
  ------HCDCRCAT--KT--RCRC--RCYTSTPT--WT--PTKTQTRTSTTG--------------------------   L   +---2    +---6cqi_A    
                                                                                       !   ! 
  ----------------------------------------------------RGAGFGTGNG----------------   L --3   +--------4rul_A    
                                                                                       ! 
  ECKC--------------DC----DCWCIG--RGRC------VC--RC--TT--------------------------   L   +------------2o5c_B

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updated Wed Dec 18 04:56:30 2024