interface graph thumbnail
legend  pdf

structure name2.42A CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS TOPOISOMERASE I IN COMPLEX WITH AN OLIGONUCLEOTIDE MTS2-11
(DNA topoisomerase 1)
referenceThirunavukkarasu et al. 'Nucleic 46 7296 2018
sourceMycobacterium tuberculosis (strain ATCC 25618 / H37Rv) / Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) / Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
experimentX-ray (resolution=2.42, R-factor=0.226)
structural superfamilyProkaryotic type I DNA topoisomerase;
sequence familyDNA topoisomerase; Toprim domain;
redundant complexes6cq2_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureHDRAKRRRYSPWPKQRST

Estimated binding specificities ?

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# IC=8.611 IC/col=1.076 n_of_columns=8 specificity:   
A |   0   0   0   0   0   4   2  14
C |   0   0  96  96   0  81   2  16
G |   0   0   0   0  96   4   4  14
T |  96  96   0   0   0   7  88  52
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ------HCDCRCAT----KT--RCRC--RCYTSTPTWT--PTKTQTRTSTTG------   L               +6cqi_A    
                                                                       +-------1 
  ----RTHCDGRG----RT----RCRC--RCYTSTPTWTKAPAKT--RTSTTG------       +---2       +6pcm_B    
                                                                   !   ! 
  ----------------------------------------------------RGAGFG   L --3   +--------4rul_A    
                                                                   ! 
  ECKC--------QGPG----DC----DCWCIG--RG------VC--RC--TT------   L   +------------2o5c_B

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updated Fri Sep 13 21:27:25 2024