interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF THE DNA BINDING DOMAINS OF HUMAN TRANSCRIPTION FACTOR ERG, HUMAN RUNX2 BOUND TO CORE BINDING FACTOR BETA (CBFB), AND MITHRAMYCIN, IN COMPLEX WITH 16MER DNA CAGAGGATGTGGCTTC
(TRANSCRIPTIONAL REGULATOR ERG)
referenceTsodikov et al. Structure 29 404 2021
sourceHOMO SAPIENS
experimentX-ray (resolution=4.31, R-factor=0.253)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyEtsdomain;
multimeric complexes5jvt_AD 6vg8_AD 6vgd_AD 6vge_AD 6vgg_AD
reference complex4iri_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKRRY

Estimated binding specificities ?

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# IC=5.807 IC/col=0.968 n_of_columns=6 specificity:   
A |  13  96   0   0  96  13
C |  13   0   0   0   0  16
G |  57   0  96  96   0  13
T |  13   0   0   0   0  54
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updated Fri Sep 13 02:35:33 2024