interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF THE DNA BINDING DOMAINS OF HUMAN TRANSCRIPTION FACTOR ERG, HUMAN RUNX2 BOUND TO CORE BINDING FACTOR BETA (CBFB), AND MITHRAMYCIN, IN COMPLEX WITH 16MER DNA CAGAGGATGTGGCTTC
(TRANSCRIPTIONAL REGULATOR ERG)
referenceTsodikov et al. Structure 29 404 2021
sourceHOMO SAPIENS
experimentX-ray (resolution=4.31, R-factor=0.253)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyEtsdomain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKRRY

Estimated binding specificities ?

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# IC=5.766 IC/col=0.961 n_of_columns=6 specificity:   
A |  54   0   0   0   0  13
C |  16   0  96  96   0  54
G |  13   0   0   0   0  13
T |  13  96   0   0  96  16
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updated Tue Dec 17 07:35:21 2024