interface graph thumbnail
legend  pdf

structure nameISCTH4 TRANSPOSASE, PRE-CLEAVED COMPLEX, PCC
referenceKosek et al. 'Embo 40 e105666 2021
experimentX-ray (resolution=3.50, R-factor=0.222)
structural superfamilyRibonuclease H-like;
sequence familyTransposase, Mutator family; MULE transposase domain;
multimeric complexes6xg8_AB 6xgw_AB
redundant complexes6xgw_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureYYNTRRYRTRSAESTVP

Estimated binding specificities ?

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# IC=17.875 IC/col=0.851 n_of_columns=21 specificity:   
A |   0   5   0   0  96  87  73  24  24  24  24   0  11   0   0   0   0  10  96  79  87
C |   0   8   0   0   0   2  10  24  24  24  24   0   8   0   0   0   0   8   0   2   5
G |  96   7  96   0   0   5   8  24  24  24  24  93  13   0  96   0  96  11   0  10   2
T |   0  76   0  96   0   2   5  24  24  24  24   3  64  96   0  96   0  67   0   5   2
scan!

Dendrogram of similar interfaces ?

matrix format
  
  YAYTNCTTRTRGYTRTTGRGSTATEAST------------------------TGVCPG   L          +-----------------------6xg8_A    
                                                                       +--6 
  ----------------------------------------NGRGTGLGLCRG------           !  +-----------------------4ew0_A    
                                                                       ! 
  ------------RA--------------ITQTNAMG----------------------   L       !                           +5zjt_E    
                                                                     +-7            +--------------1 
  ------------RT--------------IAQTNA------------------------   L     ! !            !              +5lux_K    
                                                                     ! !          +-4 
  ------------RT--------------VAQTNA------------------------   L     ! !          ! !              +3lnq_A    
                                                                   +-8 +----------5 +--------------2 
  ----------------------------IAQCNAMG----------------------   L   ! !            !                +1b72_A    
                                                                   ! !            ! 
  ------------RA--------------IAQTNAMC----------------------   L   ! !            +---------------1puf_A    
                                                                 --9 ! 
  ------------------------------------KT--------------------   L   ! +----------------------------5ejk_E    
                                                                   ! 
  --------------------------------------LTNGRGTGLCLCRG------       !                           +4ofa_A    
                                                                   +---------------------------3 
  ----------------------------------------NGRGTGLGLCRG------                                   +4e9f_A    
                                                                 

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updated Sat Jan 10 13:07:53 2026