interface graph thumbnail
legend  pdf

structure nameTHE GLUCOCORTICOID RECEPTOR IN COMPLEX WITH FLUTICASONE FUROATE, A PGC1A COACTIVATOR FRAGMENT AND SGK 23BP
(Glucocorticoid receptor)
referenceWissler et al. Nat.Struct.Mol.Biol. 30 286 2023
sourceHomo sapiens
experimentX-ray (resolution=2.70, R-factor=0.216)
structural superfamilyNuclear receptor ligand-binding domain;Glucocorticoid receptor-like DNA-binding domain;
sequence familyLigandbinding domain of nuclear hormon; Zinc finger, C4 type two domains;
multimeric complexes7prv_AB 7prw_AB
reference complex7prw_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKVR

Estimated binding specificities ?

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# IC=4.007 IC/col=0.668 n_of_columns=6 specificity:   
A |   0   0   9  24   9   9
C |   0   0   9  24  69  11
G |   0  96  11  24   9   9
T |  96   0  67  24   9  67
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updated Tue Dec 17 12:31:52 2024