1an4_A : 3D-footprint complex

structure name	STRUCTURE AND FUNCTION OF THE B/HLH/Z DOMAIN OF USF (PROTEIN UPSTREAM STIMULATORY FACTOR)
reference	'EMBO 13 180 1994
source	Homo sapiens
experiment	X-ray (resolution=2.90, R-factor=?)
structural superfamily	HLH, helix-loop-helix DNA-binding domain;
sequence family	Helixloophelix DNAbinding domain;
multimeric complexes	1an4_AB
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1an4_A interface=8,12,13,16,17,43, mdekrraQhneVErrRRdkinnwivqlskiipdssmestksgQskggilskasdyiqelrqsnhr
interface signature	QVERRQ

Estimated binding specificities ?

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# IC=4.250 IC/col=0.708 n_of_columns=6

specificity:

A |  12   0   0  96  24  12
C |  12   0   0   0  24  60
G |  60  12  96   0  24  12
T |  12  84   0   0  24  12

scan!

Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: USF
CACGTG	PubMed	1an4_AB(1.12e-07)
CACATG	PubMed	1an4_AB(1.42e-03)
CACGTGAC	PubMed	1an4_A(6.42e-03), 1an4_AB(7.20e-08)
CATGTG	PubMed	1an4_AB(1.42e-03)

Dendrogram of similar interfaces ?

matrix format

  
  RTECRGRC------   L       +-----------------------------6od3_F    
                         +-1 
  --HGNT--ET--RG   L   +-2 +-----------------------------6g1l_A    
                       ! ! 
  --HG--ITECRCRG   L --3 +-----------------------------5nj8_D    
                       ! 
  ----NT--ETRCMT       +-----------------------------2ql2_D

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updated Sun Aug 3 05:19:04 2025