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structure nameSTRUCTURE OF THE HOMEOTIC UBX/EXD/DNA TERNARY COMPLEX
(PROTEIN ULTRABITHORAX HOMEOTIC PROTEIN IV)
referenceAggarwal et al. Nature 397 714 1999
sourceDROSOPHILA MELANOGASTER
experimentX-ray (resolution=2.40, R-factor=?)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
multimeric complexes1b8i_AB 4cyc_AB 4uus_AB 4uus_EF
reference complex4cyc_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRIQNM

Estimated binding specificities ?

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# IC=4.963 IC/col=0.827 n_of_columns=6 specificity:   
A |   6   6  96   0  75  75
C |  78  75   0   6   6   9
G |   6   6   0   0   6   6
T |   6   9   0  90   9   6
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: UBX
AACCATTAAPubMed1b8i_A(8.80e-06), 1b8i_AB(7.59e-04)
ATCAATCAAPubMed1b8i_AB(3.52e-06)
TGATNNATPubMed1b8i_AB(2.74e-05)
TTAATGGTTPubMed1b8i_A(8.80e-06), 1b8i_AB(7.59e-04)

Dendrogram of similar interfaces ?

matrix format
  
  RA--------------------ITQTNAMG----   L                                      +5zjt_E    
                                                                   +----------1 
  RT--------------------NT--NAIARG--   L                           !          +1b72_B    
                                                                   ! 
  RT--------------------IAKGNA------   L                      +----8             +2hdd_A    
                                                              !    !           +-2 
  ----------------------IA--NA------                          !    ! +---------3 +4qtr_D    
                                                              !    ! !         ! 
  RT--------------------NT--NAITRG--   L                      !    +-7         +5zjt_B    
                                                           +-10      ! 
  RT------------------KTIAQCNA----RT   L                   !  !      !        +1ig7_A    
                                                           !  !      +--------4 
  RT--------------------ITQCNAACRG--   L                   !  !               +6a8r_A    
                                                        +-11  !  
  RT--------------RTQT--ITQANAVTKTKT   L                !  !  +---------------2ld5_A    
                                                        !  !  
  RT--------------------NT--NA--RG--   L                !  !                 +1b8i_B    
                                                     +-12  !  +--------------5 
  ----------------------NCITNARGRG--   L             !  !  +--9              +6fqq_E    
                                                     !  !     ! 
  --------------YTVC--KGDCKC--------   L             !  !     +---------------2qhb_A    
                                                  +-13  !  
  NGRGTG------LG--LCRG--------------              !  !  +--------------------4e9f_A    
                                                  !  !  
  RA------------------KGSAQA--------   L      +--14  !                 +---6j5b_C    
                                              !   !  +-----------------6 
  RT------------STVC--KGDCRG--------   L      !   !                    +---1w0t_A    
                                           +-15   !  
  RA--------YA----------IAQCNAYCKG--   L   !  !   +-----------------------5flv_I    
                                         -16  !  
  ----QGCGTA--LC--------------------       !  +---------------------------1orn_A    
                                           !  
  RT------------------YCNAATNAKG----   L   +-----------------------------1ic8_B    
                                         

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updated Thu Sep 12 14:32:40 2024