1e3o_C : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF OCT-1 POU DIMER BOUND TO MORE (OCTAMER-BINDING TRANSCRIPTION FACTOR 1)
reference	Schoeler et al. Mol.Cell 8 569 2001
source	Homo sapiens
experiment	X-ray (resolution=1.90, R-factor=0.220)
structural superfamily	lambda repressor-like DNA-binding domains;Homeodomain-like;
sequence family	Pou domain Nterminal to homeobox domain;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1e3o_C interface=43,44,45,48,49,55,59,118,119,122,123,126,130, eepsdleeleqfaktfkqrriklgftqgdvglamgklygndfSQTtiSRfealnLsfkNmsklkpllekwlndaekrtsietnirvaleksfmenqkptseditliaeqlnmekeviRVwfSNrrQkekRin
interface signature	SQTSRLNRVSNQR

Estimated binding specificities ?

readout + contact

# IC=6.824 IC/col=0.975 n_of_columns=7

specificity:

A |  96   0  10   0  96   0  10
C |   0  10  10  96   0   0  10
G |   0  12  66   0   0   0  66
T |   0  74  10   0   0  96  10

scan!

Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: OCT-1
ATGCAAAT	PubMed	1e3o_C(1.67e-04), 1cqt_AI(8.38e-09), 1cqt_BJ(6.42e-13), ... (total=9)
ATTTGCAT	PubMed	1e3o_C(1.67e-04), 1cqt_AI(8.38e-09), 1cqt_BJ(6.42e-13), ... (total=9)
TATGC	PubMed	1e3o_C(1.01e-03), 1cqt_AI(4.06e-03), 1cqt_BJ(5.83e-06), ... (total=5)
GCTAGCAT	PubMed	1e3o_C(5.22e-03), 1cqt_BJ(1.09e-02), 1gt0_CD(2.54e-04), ... (total=5)
AAATTAGCATGT	PubMed	1e3o_C(1.57e-03), 1cqt_AI(4.65e-03), 1cqt_BJ(3.35e-05), ... (total=7)

Dendrogram of similar interfaces ?

matrix format

  
  RA--IAQTNA----   L                               +-5ego_B    
                                    +--------------1 
  RT--NT--NAIARG   L   +------------2              +-1b72_B    
                       !            ! 
  --RTNT--NAIARG   L --3            +----------------4cyc_B    
                       ! 
  RT--VTQTNA--RG   L   +-----------------------------8ejp_B

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updated Sat Jan 10 04:34:17 2026