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structure nameCRYSTAL STRUCTURE OF THE HOMEODOMAIN OF PLATYPUS SDUX IN COMPLEX WITH DNA CONTAINING 5-BROMOURACIL
(Homeobox domain-containing protein)
referenceAihara et al. Iscience 26 107823 2023
sourceOrnithorhynchus anatinus
experimentX-ray (resolution=2.17, R-factor=0.240)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
multimeric complexes8ejo_AB 8ejp_AB
redundant complexes8ejo_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRVQNR

Estimated binding specificities ?

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# IC=5.564 IC/col=0.464 n_of_columns=12 specificity:   
A |   0   0  96   0  24  48  24  24  24  24  24  24
C |   0   0   0   0  24  24  24  24  24  24  24  36
G |   0  96   0   0  24  12  24  24  24  24  24  24
T |  96   0   0  96  24  12  24  24  24  24  24  12
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RART----VTKGNA--KA   L              +------------------2lkx_A    
                                      ! 
  --RT----IAQCNAMG--   L            +-5             +----1b72_A    
                                    ! !             ! 
  --RT--QTVAQTNA----   L            ! +-------------4 +--8osb_E    
                                    !               ! ! 
  --------NCICNARGRG   L            !               +-3   +4xrm_B    
                           +--------6                 ! +-1 
  --------NCITNARGRG   L   !        !                 +-2 +6fqq_E    
                           !        !                   ! 
  ----RT--NT--NAIARG   L --7        !                   +4cyc_B    
                           !        ! 
  --RC----IAQCNAYC--   L   !        +--------------------3rkq_B    
                           ! 
  --RT--YTNC--NAKG--   L   +-----------------------------8pi8_B

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updated Tue Jun 30 15:09:06 2026