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legend  pdf

structure nameCO-CRYSTAL STRUCTURE OF THE HNF-3/FORK HEAD DNA-RECOGNITION MOTIF RESEMBLES HISTONE H5
(HNF-3FORK HEAD DNA-RECOGNITION MOTIF)
referenceBurley et al. Nature 364 412 1993
sourceHomo sapiens
experimentX-ray (resolution=2.50, R-factor=0.211)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyFork head domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNSRHSFRR

Estimated binding specificities ?

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# IC=6.515 IC/col=0.724 n_of_columns=9 specificity:   
A |  10   0   8  96  24  24  19  96   0
C |   8   0   0   0  24  24   8   0   0
G |  17   0  71   0  24  24  17   0  96
T |  61  96  17   0  24  24  52   0   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: HNF-3
TGGACTTAGTTCAPubMed1vtn_C(2.16e-03)

Dendrogram of similar interfaces ?

matrix format
  
  --NASTRGHT--STFT----RTRA   L                    +------1vtn_C    
                                    +-------------1 
  --NASTRTHT--STLT--------   L   +--2             +------4lg0_A    
                                 !  ! 
  ----RC--YG--------KT----     --3  +--------------------2acj_B    
                                 ! 
  KT--RG--RGYA----KA------   L   +-----------------------5jvt_A    
                               

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updated Sat Jan 10 05:01:54 2026