interface graph thumbnail
legend  pdf

structure nameCO-CRYSTAL STRUCTURE OF THE HNF-3/FORK HEAD DNA-RECOGNITION MOTIF RESEMBLES HISTONE H5
(HNF-3FORK HEAD DNA-RECOGNITION MOTIF)
referenceBurley et al. Nature 364 412 1993
sourceHomo sapiens
experimentX-ray (resolution=2.50, R-factor=0.211)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyFork head domain;
multimeric complexes7vox_CH
reference complex7vox_H
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNSRHSFRR

Estimated binding specificities ?

readout + contactlogo
# IC=6.382 IC/col=0.709 n_of_columns=9 specificity:   
A |   0   0  64  24  24   0  16  96  56
C |  96   0   8  24  24   0  64   0   8
G |   0   0  16  24  24   0   8   0  16
T |   0  96   8  24  24  96   8   0  16
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: HNF-3
TGGACTTAGTTCAPubMed1vtn_C(2.16e-03)

Dendrogram of similar interfaces ?

matrix format
  
  ------------------------NAST--RGHT--STFT------------RTRA   L                                                +-1vtn_C    
                                                                                                    +---------2 
  ------------------------------RGHT--ST------------------   L                                      !         +-6akp_C    
                                                                                                +---6 
  ------------------------NGSA--RGHG--SC------------------   L                                  !   !        +--6el8_A    
                                                                                                !   +--------4 
  ----------------------QTNAST--RGHTNT----STLA------------   L                              +---9            +--2hdc_A    
                                                                                            !   ! 
  ------------------------NAST--RGHT--ST------------------   L                              !   !              +3g73_A    
                                                                                            !   !            +-1 
  ------------------------NAST--RGHTNTSTLT----------------   L                        +----10   +------------5 +7fj2_B    
                                                                                      !     !                ! 
  ------------------------NAST--RTHT--STLT----------------   L                        !     !                +--4lg0_A    
                                                                                   +-12     !  
  ------------------------NAST--RTHTNTSTLT----------------   L                     !  !     +-------------------3co6_C    
                                                                                   !  !  
  --------YC----KTHGSTQT--YTPT--------------------LG------   L                  +-13  +-------------------------5x11_A    
                                                                                !  !  
  --------------TT----RT----------------------SGRT--KT----   L                  !  !   +----------------------2v1u_A    
                                                                             +-14  +--11  
  --RGRTKG------------------------------------------------   L               !  !      +----------------------6lui_A    
                                                                             !  !  
  --------------------KT----RGAT--RGYA--------------------   L            +-15  !             +-------------4iri_A    
                                                                          !  !  +-------------8 
  ------------NT--TCTA------------------------------------   L            !  !                +-------------5zux_A    
                                                                       +-16  !  
  ------------------SGTT--TTYC----------------------------   L         !  !  +---------------------------5f7q_C    
                                                                    +-17  !  
  MG------------TGQAAT----SA------RG----------------------   L      !  !  +----------------------------2p5l_D    
                                                                    !  !  
  --------SGQG----YCNC------------------------------------       +-18  +----------------------------2ve9_C    
                                                                 !  !  
  ------------------SA------------------------------------       !  !                          +-3l4j_A    
                                                               -19  +--------------------------3 
  ----------------QAAG------------------------------------   L   !                             +-5zen_A    
                                                                 !  
  --------------------NG----RGRG--------------------------   L   !                +-----------1cf7_B    
                                                                 +----------------7 
  --------------------------------YG----------------------                        +-----------2heo_D    
                                                               

home
updated Thu Sep 12 15:38:11 2024