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structure nameANALYSIS OF THE 2.0A CRYSTAL STRUCTURE OF THE PROTEIN-DNA COMPLEX OF HUMAN PDEF ETS DOMAIN BOUND TO THE PROSTATE SPECIFIC ANTIGEN REGULATORY SITE
(SAM pointed domain containing ets transcription factor)
referenceBalderman et al. Biochemistry 44 7095 2005
sourceHomo sapiens
experimentX-ray (resolution=2.00, R-factor=0.205)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyEtsdomain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKRSRQR

Estimated binding specificities ?

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# IC=4.039 IC/col=0.808 n_of_columns=5 specificity:   
A |  74   0   0  64  64
C |  10   0   0  10  10
G |  10  96  96  12  12
T |   2   0   0  10  10
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --------KT--RGAT--RGYA--------   L                      +---------4iri_A    
                                       +------------------2 
  --------------NT--CT--NGST----   L   !                  +---------1if1_B    
                                       ! 
  ------DCKT--RG----RGYA--------   L   !                             +1dux_F    
                                       !             +---------------1 
  ------ECKT--RGAT--RGNT--------   L   !        +----3               +1pue_E    
                                     --9        !    ! 
  --------STVT------RGQTNTMT----   L   !     +--4    +----------------5d5v_B    
                                       !     !  ! 
  --------ST--------RTQT--KG----       !   +-6  +---------------------5d5w_B    
                                       !   ! ! 
  ----------RTNT--RGSTAT--RT----       ! +-7 +------------------------1t2k_B    
                                       ! ! ! 
  --KTHG------------------------       +-8 +--------------------------5hdn_C    
                                         ! 
  --------------------------KGKG   L     !   +-----------------------5xfp_B    
                                         +---5 
  RG------------------------YG--   L         +-----------------------6lui_A    
                                     

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updated Fri Sep 13 16:08:21 2024