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legend  pdf

structure nameCRYSTAL STRUCTURE OF THE DNA BINDING ETS DOMAIN OF THE HUMAN PROTEIN FEV IN COMPLEX WITH DNA
(PROTEIN FEV)
referenceBurgess-Brown et al. J.Biol.Chem. 290 13692 2015
sourceHOMO SAPIENS
experimentX-ray (resolution=2.00, R-factor=0.212)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyEtsdomain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSDKRRY

Estimated binding specificities ?

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# IC=3.340 IC/col=0.557 n_of_columns=6 specificity:   
A |   8  16  12   1   1  21
C |  31  20   9  90  94   4
G |  14  28  13   3   1  66
T |  43  32  62   2   0   5
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: ETS CRYSTAL STRUCTURE OF THE DNA BINDING ETS DOMAIN OF THE HUMAN PROTEIN FEV IN COMPLEX WITH DNA mining
ACGGAAGTPubMed3zp5_A(7.29e-03)
ACTTCCGPubMed3zp5_A(3.91e-03)
CCGGAAPubMed3zp5_A(1.33e-03)
CCGGAAGTPubMed3zp5_A(7.29e-03)
CGGAAPubMed3zp5_A(4.30e-04)
GCCGGAAPubMed3zp5_A(3.91e-03)
GCGGAAPubMed3zp5_A(1.33e-03)
GGCGGAAGTPubMed3zp5_A(1.16e-02)

Dendrogram of similar interfaces ?

matrix format
  
  ------QCKT--RGATRGNT------   L   +-----------------------------8smh_F    
                                   ! 
  --KTHG--------------------     --3                    +--------5hdn_C    
                                   !       +------------1 
  ------NCTTNA----VTNT------   L   +-------2            +--------1pp7_U    
                                           ! 
  TT----KATTQTTG--LTRTKAFTYT   L           +---------------------2p7c_B

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updated Fri Sep 13 18:00:25 2024