4uno_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THE ETS DOMAIN OF HUMAN ETV5 IN COMPLEX WITH DNA (ETS TRANSLOCATION VARIANT 5)
reference	Burgess-Brown et al. J.Biol.Chem. 290 13692 2015
source	HOMO SAPIENS
experiment	X-ray (resolution=1.95, R-factor=0.175)
structural superfamily	"Winged helix" DNA-binding domain;
sequence family	Etsdomain;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4uno_A interface=54,55,58,59,61,62, slqlwqflvtllddpanahfiawtgrgmefkliepeevarrwgiqknrpamnyDKlsRSlRYyyekgimqkvageryvykfvcdpdalfsmafpd
interface signature	DKRSRY

Estimated binding specificities ?

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# IC=4.250 IC/col=0.708 n_of_columns=6

specificity:

A |  12  24  12   0   0  12
C |  12  24  12  96  96   0
G |  12  24  12   0   0  84
T |  60  24  60   0   0   0

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: ETV5
CGGAAGTGACGTCA	PubMed	4uno_A(1.19e-02)
CCGGAAGCGGAA	PubMed	4uno_A(8.48e-03)

Dendrogram of similar interfaces ?

matrix format

  
  DCKTRGSTRGYA----   L                                +4bnc_A    
                                      +---------------1 
  DCKTRG--RGYA--KA   L        +-------2               +5jvt_A    
                              !       ! 
  ECKTRGATRGNT----   L   +----3       +----------------1pue_E    
                         !    ! 
  ----RGNTSTATRA--   L --4    +------------------------2o6g_G    
                         ! 
  QCKTRGATRGNT----   L   +-----------------------------8smh_F

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updated Mon Jun 29 18:43:50 2026