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structure nameCRYSTAL STRUCTURE OF THE ETS DOMAIN OF HUMAN ETV5 IN COMPLEX WITH DNA
(ETS TRANSLOCATION VARIANT 5)
referenceBurgess-Brown et al. J.Biol.Chem. 290 13692 2015
sourceHOMO SAPIENS
experimentX-ray (resolution=1.95, R-factor=0.175)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyEtsdomain;
redundant complexes4bnc_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureDKRSRY

Estimated binding specificities ?

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# IC=4.250 IC/col=0.708 n_of_columns=6 specificity:   
A |  12  24  12   0   0  12
C |  12  24  12  96  96   0
G |  12  24  12   0   0  84
T |  60  24  60   0   0   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: ETV5
CGGAAGTGACGTCAPubMed4uno_A(1.19e-02)
CCGGAAGCGGAAPubMed4uno_A(8.48e-03)

Dendrogram of similar interfaces ?

matrix format
  
  --------------KT--RG--RGYA------   L               +-----------------------------3wts_C    
                                                   +-1 
  ------------------TT--CT--NGKG--   L           +-2 +-----------------------------7oot_B    
                                                 ! ! 
  ------------------TT--CT--NGKG--   L         +-3 +-----------------------------7rh2_B    
                                               ! ! 
  --LT----NTHGTA--YTRG------------           +-4 +-----------------------------2efw_A    
                                             ! ! 
  --------------------NTCT--NGST--   L     +-5 +-----------------------------1if1_B    
                                           ! ! 
  ----RC--------------------------       +-6 +-----------------------------7cow_T    
                                         ! ! 
  RC------------------------------     --7 +-----------------------------6l9z_S    
                                         ! 
  ------LTNTHG--RTYTPT----------RT   L   +-----------------------------6qil_A    
                                       

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updated Fri Sep 13 18:49:00 2024