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structure nameALTERATION OF SEQUENCE SPECIFICITY OF THE TYPE II RESTRICTION ENDONUCLEASE HINCII THROUGH AN INDIRECT READOUT MECHANISM
(Type II restriction enzyme HincII)
referenceBitinaite et al. J.Biol.Chem. 281 23852 2006
sourceHaemophilus influenzae
experimentX-ray (resolution=1.83, R-factor=0.177)
structural superfamilyRestriction endonuclease-like;
multimeric complexes1kc6_CD 2gig_AB 2gih_AB 2gii_AB 2gij_AB 3e3y_AB 3e40_AB 3e41_AB 3e42_AB 3e43_AB 3e45_AB 3ebc_AB
redundant complexes1kc6_A 2gih_A 2gii_B 2gij_A 3e3y_B 3e40_B 3e41_A 3e42_A 3e43_B 3e45_A 3ebc_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureQNSFPNYNAAAQQ

Estimated binding specificities ?

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# IC=5.484 IC/col=0.914 n_of_columns=6 specificity:   
A |   0   0  10  96  11   0
C |  10  76  10   0  85  96
G |  10  10  66   0   0   0
T |  76  10  10   0   0   0
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Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: HINCII
GTCGACPubMed2gig_A(3.25e-05), 1kc6_CD(3.68e-09), 2gig_AB(4.42e-09), ... (total=10)
GTTAACPubMed2gii_AB(3.70e-09), 2gij_AB(3.66e-09), 3e3y_AB(2.51e-08), ... (total=9)
GTTGACPubMed2gig_A(7.57e-05), 1kc6_CD(1.78e-04), 2gig_AB(7.35e-05), ... (total=16)
GTTACCPubMed2gii_AB(1.67e-04), 2gij_AB(1.66e-04), 3e3y_AB(5.31e-04), ... (total=9)
CGCGTTAACGCGPubMed2gii_AB(4.53e-05), 2gij_AB(4.49e-05), 3e3y_AB(9.12e-04), ... (total=9)
GTTGAGPubMed2gig_A(7.57e-05), 3e41_A(1.55e-03), 3e43_B(1.11e-02), ... (total=5)
TGGTCTAAPubMed2gig_A(2.63e-03), 1kc6_CD(2.65e-03), 2gig_AB(3.64e-03), ... (total=10)
GGGATATCCCPubMed2gii_AB(5.69e-04), 2gij_AB(5.65e-04), 3e3y_AB(4.23e-03), ... (total=5)
TGACCPubMed2gig_A(4.74e-03), 1kc6_CD(1.77e-03), 2gig_AB(1.77e-03), ... (total=17)

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updated Sun Aug 3 06:13:20 2025