2lkx_A : 3D-footprint complex

structure name	NMR STRUCTURE OF THE HOMEODOMAIN OF PITX2 IN COMPLEX WITH A TAATCC DNA BINDING SITE (PITUITARY HOMEOBOX 3)
source	HOMO SAPIENS
experiment	NMR
structural superfamily	Homeodomain-like;
sequence family	Homeobox domain;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 2lkx_A interface=5,7,49,52,53,57, gsqrRqRthftsqqlqeleatfqrnrypdmstreeiavwtnltearvrVwfKNrraKwrkreefivtd
interface signature	RRVKNK

Estimated binding specificities ?

readout + contact

# IC=6.606 IC/col=0.944 n_of_columns=7

specificity:

A |   2   0  74  96   0  12   0
C |  74  11   2   0   0  64  96
G |  10   0  10   0   0  10   0
T |  10  85  10   0  96  10   0

scan!

Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: PITX2
TAATCC	PubMed	2lkx_A(9.63e-10)
TAATC	PubMed	2lkx_A(7.97e-07)

Dendrogram of similar interfaces ?

matrix format

  
  --RARA--------IAQTNA------   L        +---------------5ego_B    
                                   +----3 
  RC--RT------YANC--NAKG----   L   !    !              +4j19_B    
                                   !    +--------------2 
  ----RT--------NT--NA--IARG   L --4                   +1b72_B    
                                   ! 
  --------YTVCKGDCKC--------   L   !                    +2qhb_A    
                                   +--------------------1 
  ------RT------NT--NAIARG--   L                        +4cyc_B

home
updated Sat Jan 10 05:23:47 2026