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structure nameNMR STRUCTURE OF THE HOMEODOMAIN OF PITX2 IN COMPLEX WITH A TAATCC DNA BINDING SITE
(PITUITARY HOMEOBOX 3)
sourceHOMO SAPIENS
experimentNMR
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRVKNK

Estimated binding specificities ?

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# IC=6.674 IC/col=0.953 n_of_columns=7 specificity:   
A |   0  10  96   0  12  85  12
C |   0  10   0   0  10   1  10
G |  96  64   0   0   0  10  74
T |   0  12   0  96  74   0   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: PITX2
TAATCCPubMed2lkx_A(9.63e-10)
TAATCPubMed2lkx_A(7.97e-07)

Dendrogram of similar interfaces ?

matrix format
  
  --KGRT----IAQCNAYA----RT--   L                              +1nk2_P    
                                             +----------------3 
  --RCRT----NT--NA--ITRG----       +---------8                +5zjt_B    
                                   !         ! 
  ----RT----NT--NA--IARG----   L   !         +-----------------1b72_B    
                                   !  
  ----RT----VAQTNA----------   L   !                            +5hod_A    
                                   !                    +-------1 
  --RTRT----IAKGNA----------   L   !            +-------5       +6m3d_C    
                                   !            !       ! 
  ----RA--RCVTCTNAQTRC------   L -11         +--7       +--------1au7_A    
                                   !         !  ! 
  ----RT--FTYAQTNAATRG------   L   !         !  !           +----6ryd_F    
                                   !         !  +-----------4 
  --------RTVAITNAMCRG------   L   !  +------9              +----1yrn_A    
                                   !  !      ! 
  RC--RT--------ITQCNA--ACRG   L   !  !      !                  +6a8r_A    
                                   !  !      !  +---------------2 
  ------RT--NCSTNARG--------   L   +-10      +--6               +1mnm_C    
                                      !         ! 
  --------RCVACTNAQA--------   L      !         +----------------7xrc_C    
                                      !  
  ----RA----YAQTNAAARG------   L      +--------------------------6wig_A    
                                 

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updated Fri Sep 13 16:29:24 2024