2lkx_A : 3D-footprint complex

structure name	NMR STRUCTURE OF THE HOMEODOMAIN OF PITX2 IN COMPLEX WITH A TAATCC DNA BINDING SITE (PITUITARY HOMEOBOX 3)
source	HOMO SAPIENS
experiment	NMR
structural superfamily	Homeodomain-like;
sequence family	Homeobox domain;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 2lkx_A interface=5,7,49,52,53,57, gsqrRqRthftsqqlqeleatfqrnrypdmstreeiavwtnltearvrVwfKNrraKwrkreefivtd
interface signature	RRVKNK

Estimated binding specificities ?

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# IC=6.675 IC/col=0.954 n_of_columns=7

specificity:

A |   0   0  74  96   0  12   0
C |  74  10   2   0   0  64  96
G |  12   0  10   0   0  10   0
T |  10  86  10   0  96  10   0

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: PITX2
TAATCC	PubMed	2lkx_A(9.63e-10)
TAATC	PubMed	2lkx_A(7.97e-07)

Dendrogram of similar interfaces ?

matrix format

  
  RCRT------YANC--NAKG--   L                       +4j19_B    
                                                 +-1 
  ----RT------NT--NAIARG   L   +-----------------2 +4cyc_B    
                               !                 ! 
  ------------NCITNARGRG   L --3                 +-6fqq_E    
                               ! 
  ------YTVCKGDCKC------   L   +-------------------2qhb_A

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updated Mon Jun 29 15:22:11 2026