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structure nameSTRUCTURE OF A NOVEL TELOMERE REPEAT BINDING PROTEIN BOUND TO DNA
(Homeobox-containing protein 1)
referenceLondono-Vallejo et al. 'Embo 32 1681 2013
sourceHomo sapiens
experimentX-ray (resolution=2.90, R-factor=0.174)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
multimeric complexes4j19_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRYNNK

Estimated binding specificities ?

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# IC=5.074 IC/col=0.846 n_of_columns=6 specificity:   
A |   0   0   8   8  72   0
C |   0   0   8   8   8   8
G |  96  96   8   8   8  80
T |   0   0  72  72   8   8
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ------RA------YAQTNAAARG--   L                   +-----------------------------6wig_A    
                                                 +-1 
  --KG--RT------IAQCNAYA--RT   L               +-2 +-----------------------------1nk2_P    
                                               ! ! 
  ------RT------VAQTNA------   L             +-3 +-----------------------------5hod_A    
                                             ! ! 
  ------RT------NT--NAIARG--   L           +-4 +-----------------------------1b72_B    
                                           ! ! 
  --RC--RT------NT--NAITRG--             +-5 +-----------------------------5zjt_B    
                                         ! ! 
  ----------RT--YT----------   L       +-6 +-----------------------------7pik_B    
                                       ! ! 
  RC----RT------ITQCNAACRG--   L     +-7 +-----------------------------6a8r_A    
                                     ! ! 
  ------RT----FTYAQTNAATRG--   L   +-8 +-----------------------------6ryd_F    
                                   ! ! 
  ------RA----RCVTCTNAQTRC--   L --9 +-----------------------------1au7_A    
                                   ! 
  ----RC--RT----NCSTNARG----   L   +-----------------------------1mnm_C    
                                 

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updated Fri Sep 13 18:24:47 2024