6fqq_E : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF TALE HOMEOBOX DOMAIN TRANSCRIPTION FACTOR TGIF1 DOUBLE ALANINE MUTANT BOUND TO ITS CONSENSUS DNA (Homeobox protein TGIF1)
reference	Macias et al. 'Nucleic 46 9220 2018
source	Homo sapiens
experiment	X-ray (resolution=3.25, R-factor=0.218)
structural superfamily	Homeodomain-like;
multimeric complexes	6fqq_AB 6fqq_DE
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6fqq_E interface=45,48,49,52,53, gnlpkesvqilrdwlyehrynaypseqekallsqqthlstlqvcNwfINarRRllpdmlrk
interface signature	NINRR

Estimated binding specificities ?

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# IC=4.687 IC/col=0.937 n_of_columns=5

specificity:

A |   1   1   0   3  49
C |   3   0   1  86  14
G |   1  95   1   4  17
T |  91   0  94   3  16

scan!

Dendrogram of similar interfaces ?

matrix format

  
  ----------NT--NAIARG   L       +-----------------------------4cyc_B    
                               +-1 
  ----------VTQTNA--RG   L   +-2 +-----------------------------8ejp_B    
                             ! ! 
  STRGQTQAST----------   L --3 +-----------------------------7t8k_B    
                             ! 
  ------STTAQCST------       +-----------------------------8b4b_W

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updated Mon Jun 29 22:57:42 2026