interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF TALE HOMEOBOX DOMAIN TRANSCRIPTION FACTOR TGIF1 DOUBLE ALANINE MUTANT BOUND TO ITS CONSENSUS DNA
(Homeobox protein TGIF1)
referenceMacias et al. 'Nucleic 46 9220 2018
sourceHomo sapiens
experimentX-ray (resolution=3.25, R-factor=0.218)
structural superfamilyHomeodomain-like;
multimeric complexes6fqq_AB 6fqq_DE
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNINRR

Estimated binding specificities ?

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# IC=4.687 IC/col=0.937 n_of_columns=5 specificity:   
A |   1   1   0   3  49
C |   3   0   1  86  14
G |   1  95   1   4  17
T |  91   0  94   3  16
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --------ITQCNAMC--   L     +-----------------------------2r5y_A    
                           +-2 
  --------VA--NAQART   L   ! !                           +-1o4x_A    
                         --3 +---------------------------1 
  --------VTCCNAQART   L   !                             +-8g87_X    
                           ! 
  DTRTRGTTKT--------   L   +-----------------------------2o8k_A    
                         

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updated Fri Sep 13 21:43:53 2024