2xkk_C : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF MOXIFLOXACIN, DNA, AND A. BAUMANNII TOPO IV (PARE-PARC FUSION TRUNCATE) (TOPOISOMERASE IV)
reference	Shillings et al. Nat.Struct.Mol.Biol. 17 1152 2010
source	ACINETOBACTER BAUMANNII
experiment	X-ray (resolution=3.25, R-factor=0.197)
structural superfamily	Type II DNA topoisomerase;
sequence family	DNA gyrase/topoisomerase IV, subunit A; DNA gyrase B subunit, carboxyl terminus;
multimeric complexes	2xkk_AC
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 2xkk_C interface=57,257,309,399,553, erkkivsgpalpgkladcvgqtreeselfivegdsaggsakqardknfqaimpirgKilntwevssdevlasqevhdiaiaigvdpgsddlselrygkiciladadsdglhiatllcalfvkhfpalveeghlyvampplfridigkdvhyalddeeletilknvknpqitrfkglgemnaiqlrettmdpntrrlvqldlddahltaglldkllakkraadrkqwleqkgatenrsvaefteqaylnyamyvimdRalphisdglkpvqrrivyamselglkssgkpkksartvgdvlgkyhphgdsAcyeamvlmaqpfsyrypliegqgnwgspddpksfaamrteaklsayselllselgqgtsewqdnfdgslkepitlparvpnillngttgIavgmatdipphnlrevvkgtialirnpqtsdeklaeyipapdlptkaeiitppeellkiqttgrgsyrmravytiekneivitelpyqvsgskvitqiadqmqakklplvvdvrdesdhenptrlvivlrsnridaeavmshlfattdlessyRvnlnmigedgrpqvksirrillewieirkktvtrrlqyhlnriekrlhilaglliayldidtviriireedqpkpvlmehfnideiqaeailelklrhlakleemeirheqdelsakaaiireqlenpeslknliiselkedakkfgderrspivar
interface signature	KRAIR

Estimated binding specificities ?

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# IC=5.105 IC/col=0.729 n_of_columns=7

specificity:

A |   8   1   0   0  24  69   8
C |  69   8   0   0  24   8  11
G |   8  87   0  96  24  11   8
T |  11   0  96   0  24   8  69

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Dendrogram of similar interfaces ?

matrix format

  
  KA------SA--------------RGIG----------             +-----------------------------2xcr_U    
                                                   +-1 
  --RC----ST----------------IA----------         +-2 +-----------------------------3ksb_B    
                                                 ! ! 
  ------------NARGHT--STLT--------------   L   +-3 +-----------------------------7cby_C    
                                               ! ! 
  ----DCLTAGTTRG----RG------------------   L --4 +-----------------------------5h3r_A    
                                               ! 
  ----------------------------NTATATSTRG   L   +-----------------------------1dh3_C

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updated Fri Sep 13 16:47:53 2024