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structure nameSTRUCTURE OF A HOMEODOMAIN IN COMPLEX WITH DNA
(Paired box protein Pax-3)
referenceLadias et al. Biochemistry 48 1148 2009
sourceHomo sapiens
experimentX-ray (resolution=1.95, R-factor=0.174)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRRVSN

Estimated binding specificities ?

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# IC=5.339 IC/col=0.890 n_of_columns=6 specificity:   
A |  69   0  96  96   9   9
C |   9   0   0   0   9  67
G |   9   0   0   0  11  11
T |   9  96   0   0  67   9
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: PAX3
TAATCPubMed3cmy_A(1.23e-07)
TAATANPubMed3cmy_A(1.13e-03)

Dendrogram of similar interfaces ?

matrix format
  
  RARA--IAQTNA----   L                  +-5ego_B    
                         +--------------1 
  --RT--NT--NAIARG   L   !              +-1b72_B    
                       --3 
  RCRT--VTQTNA--RG   L   !            +---8ejp_B    
                         +------------2 
  ----RTNT--NAIARG   L                +---4cyc_B    
                       

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updated Sat Jan 10 05:47:50 2026