interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF A REX-FAMILY REPRESSOR/DNA/NAD+ COMPLEX FROM THERMUS AQUATICUS
(Redox-sensing transcriptional repressor rex)
referenceMcLaughlin et al. Mol.Cell 38 563 2010
sourceThermus thermophilus HB27
experimentX-ray (resolution=2.26, R-factor=0.234)
structural superfamilyNADP-binding Rossmann-fold domains;"Winged helix" DNA-binding domain;
sequence familyCoA binding domain; Putative DNAbinding protein Nterminu;
multimeric complexes3ikt_AB 3il2_AB
redundant complexes3il2_B
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureFQRKSYR

Estimated binding specificities ?

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# IC=7.181 IC/col=1.026 n_of_columns=7 specificity:   
A |  13  13   0   0   0   0  96
C |  13  57   0   0   0   0   0
G |  57  13   0  96   0  96   0
T |  13  13  96   0  96   0   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: Rex
TTCACAAPubMed3ikt_B(5.18e-05), 3ikt_AB(4.93e-03)
TTGTGAANNNNTTCACAAPubMed3ikt_B(4.94e-03), 3ikt_AB(6.49e-07)

Dendrogram of similar interfaces ?

matrix format
  
  FAQTRGKGSTYTRG--   L           +3ikt_B    
                         +-------1 
  SAQTRGQTNG--QT--   L   !       +3wgi_D    
                       --3 
  ATTTRGRGSTYTRA--   L   !       +3ket_A    
                         +-------2 
  SC--RGKGST--RAVA   L           +7wb3_B    
                       

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updated Fri Sep 13 17:07:52 2024