interface graph thumbnail
legend  pdf

structure nameSTRUCTURE OF THE SOX4 HMG DOMAIN BOUND TO DNA
(Transcription factor SOX-4)
referenceKolatkar et al. Biochem.J. 443 39 2012
sourceMus musculus
experimentX-ray (resolution=2.40, R-factor=0.238)
structural superfamilyHMG-box;
sequence familyHMG high mobility group box;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRNFMRHNASY

Estimated binding specificities ?

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# IC=6.939 IC/col=0.991 n_of_columns=7 specificity:   
A |  96   0  96  96  12  84  12
C |   0  96   0   0   0  12  12
G |   0   0   0   0  24   0  48
T |   0   0   0   0  60   0  24
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: SOX4
CCAATPubMed3u2b_C(1.01e-03)

Dendrogram of similar interfaces ?

matrix format
  
  RTNGFTIARA--NASGST--YAPG   L   +-----------------------------1j46_A    
                                 ! 
  RTNTFTMARA--NGACST--YA--   L   !                             +4s2q_D    
                                 !                    +--------1 
  RCNAFTIARG--NC--SALTYAKT   L --5         +----------2        +2gzk_A    
                                 !         !          ! 
  RGNTFTMART--NGRTSA--WANT   L   !      +--3          +--------7m5w_A    
                                 !      !  ! 
  RCNGFTMARTHTNG--ST--YA--   L   +------4  +-------------------6t90_L    
                                        ! 
  RCNTFTMARAHGNAACST------   L          +----------------------4euw_A    
                               

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updated Fri Sep 13 17:45:08 2024