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structure nameTHE 3D STRUCTURE OF THE HUMAN SRY-DNA COMPLEX SOLVED BY MULTID- DIMENSIONAL HETERONUCLEAR-EDITED AND-FILTERED NMR
experimentNMR
structural superfamilyHMG-box;
sequence familyHMG high mobility group box;
redundant complexes1hrz_A 1j46_A 1j47_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNFIRSSY

Estimated binding specificities ?

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# IC=5.766 IC/col=0.961 n_of_columns=6 specificity:   
A |  13  16   0   0   0   0
C |  16  13   0   0   0   0
G |  54  13   0   0  96   0
T |  13  54  96  96   0  96
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: SRY
AACAATPubMed1hry_A(1.12e-03), 1hrz_A(1.12e-03)
AACAAAGPubMed1hry_A(6.36e-06), 1hrz_A(6.24e-06)
NACAATPubMed1hry_A(1.12e-03), 1hrz_A(1.12e-03)
CTTTGPubMed1hry_A(3.59e-04), 1hrz_A(3.54e-04)
ACAATPubMed1hry_A(3.54e-04), 1hrz_A(3.54e-04)
GAACAATPubMed1hry_A(3.37e-03), 1hrz_A(3.37e-03)
ATTGTTPubMed1hry_A(1.12e-03), 1hrz_A(1.12e-03)
TCAAAGPubMed1hry_A(1.13e-03), 1hrz_A(1.12e-03)

Dendrogram of similar interfaces ?

matrix format
  
  RTNGFTIARA--NASG--STYA   L   +-----------------------------1j47_A    
                               ! 
  --NAFTIARC----SGICSTYA   L --3                             +1hry_A    
                               !             +---------------1 
  RTNGFTMART--NTAT--SAYA   L   +-------------2               +6t78_A    
                                             ! 
  RCNGFTMARTHTNG----STYA   L                 +---------------6t90_L

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updated Fri Sep 13 15:38:47 2024