interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF THE DNA-BINDING DOMAIN OF HUMAN ETV1 COMPLEXED WITH DNA
(HUMAN ETV1)
referenceArrowsmith et al. J.Biol.Chem. 290 13692 2015
sourceHOMO SAPIENS
experimentX-ray (resolution=2.90, R-factor=0.207)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyEtsdomain;
reference complex4uno_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureDKRSRY

Estimated binding specificities ?

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# IC=4.170 IC/col=0.695 n_of_columns=6 specificity:   
A |  19   9   5   6   0   6
C |  45   9   3  78  96   6
G |  16   9   3   6   0  78
T |  16  69  85   6   0   6
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --------------KT--RG--RGYA------   L                    +--------------3wts_C    
                                                  +-------2 
  ----RC--------------------------              +-3       +--------------7cow_T    
                                                ! ! 
  ------------------TT--CT--NGKG--   L        +-4 +----------------------7oot_B    
                                              ! ! 
  ------------------TT--CT--NGKG--   L     +--5 +------------------------7rh2_B    
                                           !  ! 
  --------------------NTCT--NGST--   L   +-6  +--------------------------1if1_B    
                                         ! ! 
  ------LTNTHG--RTYTPT----------RT   L   ! !                 +-----------6qil_A    
                                       --7 +-----------------1 
  --LT----NTHGTA--YTRG------------       !                   +-----------2efw_A    
                                         ! 
  RC------------------------------       +-----------------------------6l9z_S    
                                       

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updated Thu Sep 12 18:51:38 2024