interface graph thumbnail
legend  pdf

structure namePU.1 ETS DOMAIN-DNA COMPLEX
(PROTEIN TRANSCRIPTION FACTOR PU.1 TF PU.1)
referenceKodandapani et al.
sourceMus musculus
experimentX-ray (resolution=2.10, R-factor=0.225)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyEtsdomain;
multimeric complexes8ek8_EF
reference complex8ee9_F
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureEKRARN

Estimated binding specificities ?

readout + contactlogo
# IC=4.253 IC/col=0.851 n_of_columns=5 specificity:   
A |  24   0   0   0   0
C |  12  24  96  96  72
G |  12   0   0   0  12
T |  48  72   0   0  12
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: PU.1
GTGGGAAPubMed1pue_E(1.20e-03)
CAGGAACPubMed1pue_E(7.03e-03)

Dendrogram of similar interfaces ?

matrix format
  
  ----ECKT--RGAT--RGNT--------   L                                +-1pue_E    
                                                              +---5 
  ----DCKT--RG----RGYA--------   L                            !   +-1dux_F    
                                                      +-------6 
  ------STVT------RGQTNT--MT--   L                    !       !     +5d5v_B    
                                                 +----9       +-----3 
  ------ST--------RTQT--KG----                   !    !             +5d5w_B    
                                                 !    ! 
  ------KT--RGAT--RGYT--------   L            +-12    +-------------1awc_A    
                                              !  !  
  ------KT--RGSA--RGQA------RA   L            !  !        +---------1yo5_C    
                                         +---13  +--------8 
  ----------RTNT--STAT--RT----           !    !           +---------1t2k_B    
                                         !    !  
  KTHG------------------------           !    +-------------------5hdn_C    
                                         !  
  ------KT--RGAT--RGYA--------   L       !                        +4iri_A    
                                     +--15        +---------------2 
  ------KT--RG----RAYA--------   L   !   !        !               +6vge_A    
                                     !   !   +---10  
  ----DCKT--RG----RGYA----KA--   L   !   !   !    !              +5jvt_A    
                                     !   !   !    +--------------4 
  ----DCKT--RGAT--RCYA--------   L   !   !   !                   +5e8i_D    
                                     !   +--14  
  ----ECKT--RGAT--RGHT------RA   L -16       !                    +4mhg_A    
                                     !       !   +----------------1 
  ------KT--RG----RGYA--------   L   !       !   !                +3wts_C    
                                     !       +--11  
  ----DCKT--RG----RGYA--------   L   !           !      +---------3zp5_A    
                                     !           +------7 
  ----------NT--RGCT--NGST----   L   !                  +---------1if1_B    
                                     !  
  ----------------RG--NG------       +----------------------------7dci_A    
                                   

home
updated Thu Sep 12 15:19:01 2024