structure nameCRYSTAL STRUCTURE OF IRF-3 BOUND TO THE INTERFERON-B ENHANCER
(Interferon regulatory factor 3)
reference'Cell(Cambridge,Mass.)' 129 1111 2007
sourceHomo sapiens
experimentX-ray (resolution=3.10, R-factor=?)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyInterferon regulatory factor transcription f;
multimeric complexes2o6g_EFGH
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureHLRNRSAR

Estimated binding specificities ?

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# IC=5.766 IC/col=0.641 n_of_columns=9 specificity:   
A |  54  24  24  24   0  13  96  96  96
C |  13  24  24  24   0  13   0   0   0
G |  16  24  24  24  96  54   0   0   0
T |  13  24  24  24   0  16   0   0   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  HT------ATNTRGCT----SC   L                            +--------8hcm_A    
                                   +--------------------1 
  --DCKT----RG--RGYA----   L     +-2                    +--------3zp5_A    
                                 ! ! 
  --------NASTRTHTNTSTLT   L   +-3 +-----------------------------3co6_C    
                               ! ! 
  ------DCST--RGHGNTST--   L --4 +-----------------------------7yzb_A    
                               ! 
  --DCKT--RGST--RGYC----   L   +-----------------------------4uno_A

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updated Mon Jun 29 15:28:02 2026