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structure nameSTRUCTURE OF MITOCHONDRIAL RNA POLYMERASE ELONGATION COMPLEX
(DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL)
referenceSchwinghammer et al. Nat.Struct.Mol.Biol. 20 1298 2013
sourceHOMO SAPIENS
experimentX-ray (resolution=2.65, R-factor=0.181)
structural superfamilyDNA/RNA polymerases;
sequence familyDNAdependent RNA polymerase;
multimeric complexes6erp_ACF 6erp_BGJ 6erq_ACF 6erq_BGJ
redundant complexes6erq_B 6erp
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureQSRISEQTYVYQWER

Estimated binding specificities ?

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# IC=9.003 IC/col=0.750 n_of_columns=12 specificity:   
A |   7   0   0   0  24  24  24   7   7   7   0   0
C |  75   0   0   0  24  24  24   7  73  73   0  96
G |   7  96   0  96  24  24  24  75   9   7  96   0
T |   7   0  96   0  24  24  24   7   7   9   0   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  QGSC--RG--------IC--------SC----EG----------QG--TGYGVG--YT--QG--WGEG--RG--------   L                    +-----------4boc_A    
                                                                                                       +--5 
  ----YTHASAKT----------------------------------------------------------RG--------   L     +-----------6  +-----------6ymv_A    
                                                                                           !           ! 
  ------------------ATYTDGKG------------RCRCYC----TTYT----FART--IG------------HT--   L     !           +--------------1msw_D    
                                                                                           ! 
  ----------------------------KC----------RT--TC----YCMCSAHA----------------QG----         !                        +-6fbc_A    
                                                                                         +-8                      +-3 
  ----------------------------------------------FC--YG--------------------NGQC----   L   ! !                      ! +-1tau_A    
                                                                                         ! !           +----------4 
  ----------------------------KT----YG----RG----YG--YAIGSCYC----------RC----QA--HG       ! !           !          ! +-4yfu_D    
                                                                                         ! !           !          +-2 
  ------------------------------RC--------RA----YG--YT--SCYC----------------------   L --9 +-----------7            ! +6vdd_A    
                                                                                         !             !            +-1 
  ------------------------------------VC------------------------------------------       !             !              +1kln_A    
                                                                                         !             ! 
  ------------------------------------------RT------YA----------------------QA----       !             +--------------1x9m_A    
                                                                                         ! 
  ------------IAVA----------------------RC--YC------------------------------------       +----------------------------6dta_A    
                                                                                       

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updated Fri Sep 13 18:05:21 2024