interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF THE ETS DOMAIN OF HUMAN ETS2 IN COMPLEX WITH DNA
(PROTEIN C-ETS-2)
referenceArrowsmith et al. J.Biol.Chem. 290 8539 2015
sourceHOMO SAPIENS
experimentX-ray (resolution=2.50, R-factor=0.235)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyEtsdomain;
multimeric complexes4bqa_ADG
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKRRY

Estimated binding specificities ?

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# IC=4.250 IC/col=0.850 n_of_columns=5 specificity:   
A |  12   0   0  84  60
C |  60   0   0  12  12
G |  12  96  96   0  12
T |  12   0   0   0  12
scan!

Dendrogram of similar interfaces ?

matrix format
  
  ------KT--RG--RGYT--   L                      +------4bqa_A    
                                             +--1 
  ------KT--RG--RGYA--   L   +---------------2  +------4l18_B    
                             !               ! 
  ----ECKT--RGATRGHTRA   L --3               +---------4mhg_A    
                             ! 
  ITRGECSCSGKG--------   L   +-------------------------5i2d_R

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updated Tue Dec 19 08:39:32 2023