4mhg_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF ETV6 BOUND TO A SPECIFIC DNA SEQUENCE (Transcription factor ETV6)
reference	Coyne III et al. J.Mol.Biol. 426 1390 2014
source	Mus musculus
experiment	X-ray (resolution=2.20, R-factor=0.177)
structural superfamily	"Winged helix" DNA-binding domain;
sequence family	Etsdomain;
redundant complexes	8e66_F 8e67_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4mhg_A interface=54,55,57,58,59,61,62,76, rllwdyvyqllsdsryenfirwedkeskifrivdpnglarlwgnhknrtnmtyEKmSRAlRHyyklniirkepgqRllfrfmktpdeims
interface signature	EKSRARHR

Estimated binding specificities ?

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# IC=7.043 IC/col=0.880 n_of_columns=8

specificity:

A |  54  24   0   0   0   0  68  96
C |  13  24  96  82   0   0   0   0
G |  13  24   0   0  96  96  15   0
T |  16  24   0  14   0   0  13   0

scan!

Dendrogram of similar interfaces ?

matrix format

  
  DCKT--RG----RGYAKA--   L       +-----------------------------5jvt_A    
                                 ! 
  DCKT--RGST--RGYA----   L     +-3                          +--4bnc_A    
                               ! !       +------------------1 
  ECKT--RGAT--RGNT----   L     ! +-------2                  +--1pue_E    
                             +-4         ! 
  ----RGNT--RGSTAT----   L   ! !         +---------------------2o6g_G    
                           --5 ! 
  QCKT--RGAT--RGNT----   L   ! +-----------------------------8smh_F    
                             ! 
  ------------------KG   L   +-----------------------------5xfq_A

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updated Mon Jun 29 18:16:18 2026