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legend  pdf

structure nameCRYSTAL STRUCTURE OF ETV6 BOUND TO A SPECIFIC DNA SEQUENCE
(Transcription factor ETV6)
referenceCoyne III et al. J.Mol.Biol. 426 1390 2014
sourceMus musculus
experimentX-ray (resolution=2.20, R-factor=0.177)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyEtsdomain;
redundant complexes8e66_F 8e67_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureEKSRARHR

Estimated binding specificities ?

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# IC=5.937 IC/col=0.990 n_of_columns=6 specificity:   
A |   0  16   0   0  16   0
C |  16  16  96  96   0   0
G |   0  16   0   0  80  96
T |  80  48   0   0   0   0
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Dendrogram of similar interfaces ?

matrix format
  
  ------------KT--RG--RGYA------   L                                      +4l18_B    
                                                     +--------------------1 
  ------------KT--RG--RGYA------   L              +--2                    +3wts_C    
                                                  !  ! 
  ----------------TT--CT--NGKG--   L            +-3  +---------------------7oot_B    
                                                ! ! 
  ----------------TT--CT--NGKG--   L          +-4 +------------------------7rh2_B    
                                              ! ! 
  --RC--------------------------           +--5 +-------------------------7cow_T    
                                           !  ! 
  ------------------NTCT--NGST--   L     +-6  +--------------------------1if1_B    
                                         ! ! 
  ----RAST--ECTTRAKA------------       +-7 +-----------------------------7oz3_B    
                                       ! ! 
  ------NT--TCTA--------------RT   L --8 +-----------------------------5zux_A    
                                       ! 
  LT----NTHGTA--YTRG------------       +-----------------------------2efw_A    
                                     

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updated Fri Sep 13 18:31:44 2024