interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF E43A ISCR MUTANT BOUND TO ITS PROMOTER
(HTH-type transcriptional regulator IscR)
referenceRajagopalan et al. Nat.Struct.Mol.Biol. 20 740 2013
sourceEscherichia coli
experimentX-ray (resolution=2.99, R-factor=0.233)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyTranscriptional regulator;
multimeric complexes4chu_AB 4hf1_AB 4hf2_AB
reference complex4hf1_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSSYQRP

Estimated binding specificities ?

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# IC=1.719 IC/col=0.191 n_of_columns=9 specificity:   
A |  19   2  60  19  24  24  19  20  18
C |  19   1  12  19  24  24  19  22  18
G |  39   1  12  19  24  24  20  20  18
T |  19  92  12  39  24  24  38  34  42
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updated Fri Jan 9 00:42:54 2026