interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF E43A ISCR MUTANT BOUND TO ITS PROMOTER
(HTH-type transcriptional regulator IscR)
referenceRajagopalan et al. Nat.Struct.Mol.Biol. 20 740 2013
sourceEscherichia coli
experimentX-ray (resolution=2.99, R-factor=0.233)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyTranscriptional regulator;
multimeric complexes4chu_AB 4hf1_AB 4hf2_AB
reference complex4hf1_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSSYQRP

Estimated binding specificities ?

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# IC=6.459 IC/col=0.718 n_of_columns=9 specificity:   
A |  90  42  72  24  24  84   0  96   6
C |   0  24   0  24  24   6   0   0  84
G |   0  18  24  24  24   0   0   0   0
T |   6  12   0  24  24   6  96   0   6
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updated Sun Jun 28 10:16:58 2026