4hf1_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF ISCR BOUND TO ITS PROMOTER (HTH-type transcriptional regulator IscR)
reference	Rajagopalan et al. Nat.Struct.Mol.Biol. 20 740 2013
source	Escherichia coli
experiment	X-ray (resolution=2.22, R-factor=0.205)
structural superfamily	"Winged helix" DNA-binding domain;
sequence family	Transcriptional regulator;
multimeric complexes	4chu_AB 4hf1_AB 4hf2_AB
redundant complexes	4chu_A 4hf2_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4hf1_A interface=38,40,41,43,44,59,61, mrltskgryavtamldvalnseagpvpladiserqgiSlSYlEQlfsrlrknglvssvRgPgggyllgkdassiavgevisavdesvdalthalwrdlsdrltgflnnitlgelvnnqevldvsgrqht
interface signature	SSYEQRP

Estimated binding specificities ?

readout + contact

# IC=2.129 IC/col=0.426 n_of_columns=5

specificity:

A |   2  66  24  11   7
C |   5   8  24   9   8
G |   3  14  22  50  73
T |  86   8  26  26   8

scan!

Dendrogram of similar interfaces ?

matrix format

  
  TT------KATTQTTGLTRTKA--FTYT   L                               +-----2p7c_B    
                                         +-----------------------1 
  --------------RCYG----KT----         +-2                       +-----2acj_B    
                                       ! ! 
  ----------------YG----------       +-3 +-----------------------------3eyi_B    
                                     ! ! 
  --VTSARGTA--RT--------------   L --4 +-----------------------------6za3_B    
                                     ! 
  ----EGRTRGRGYT--------------   L   +-----------------------------4yo2_A

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updated Sat Jan 10 07:07:03 2026