4qcl_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THE CATALYTIC CORE OF HUMAN DNA POLYMERASE ALPHA IN TERNARY COMPLEX WITH AN RNA-PRIMED DNA TEMPLATE AND DCTP (DNA POLYMERASE ALPHA CATALYTIC SUBUNIT)
reference	Baranovskiy et al. J.Biol.Chem. ? ? 2018
source	HOMO SAPIENS
experiment	X-ray (resolution=2.20, R-factor=0.210)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
sequence family	DNA polymerase family B; DNA polymerase family B, exonuclease do;
multimeric complexes	8d0b_ABF
redundant complexes	4q5v 5iud 6as7 7n2m
reference complex	8d0b_F
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4qcl_A interface=443,468,499,572,575,576,578,583,585,674,675,704, eqvfhfywldayedqynqpgvvflfgkvwiesaethvsccvmvkniertlyflpremkidlntgketgtpismkdvyeefdekiatkykimkfkskpveknyafeipdvpekseylevkysaempqlpqdlkgetfshvfgtntsslelflmnrkikgpcwlevkspqllnqpvswckaeamalkpdlvnvikdvsppplvvmafsmktmqnaknhqneiiamaalvhhsfaldkaapkppfqshfcvvskpkdcifpyafkeviekknvkvevaatertllgfflakvhkidpdiivghniygfelevllqrinvckaphwskigrlkrsnmpklgfgernatcgrmicdveisakelircksyhlselvqqilktervvipmeniqnmysessqllyllehtwkdakfilqimcelnvlplalqitniagnimsrtlmggRserneflllhafyennyivpdkqiRkkaayagglvldpkvgfydkfillldfnslYpsiiqefnicfttvqrveqipelpdpslemgilpreirklverrkqvkqlmkqqdlnpdlilqydirqkalkLtaNSmYgclgFsYsrfyakplaalvtykgreilmhtkemvqkmnleviygdtdsimintnstnleevfklgnkvksevnklyklleididgvfksllllkkKKyaalvveptsdgnyvtkqelkgldivrrDwcdlakdtgnfvigqilsdqsrdtiveniqkrlieigenvlngsvpvsqfeinkaltkdpqdypdkkslphvhvalwinsqggrkvkagdtvsyvicqdgsnltasqrayapeqlqkqdnltidtqyylaqqihpvvaricepidgidavliatwlgldpt
interface signature	RRYLNSYFYKKD

Estimated binding specificities ?

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# IC=5.455 IC/col=0.909 n_of_columns=6

specificity:

A |  96   0  21   0   0  16
C |   0   0  21  96   0  45
G |   0  96  31   0  96  19
T |   0   0  23   0   0  16

scan!

Dendrogram of similar interfaces ?

matrix format

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updated Sat Aug 2 07:10:37 2025