5ean_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF DNA2 IN COMPLEX WITH A 5' OVERHANG DNA (DNA replication ATP-dependent helicasenuclease DNA2)
reference	Pavletich et al. Elife 4 ? 2015
source	Mus musculus
experiment	X-ray (resolution=2.36, R-factor=0.209)
structural superfamily	P-loop containing nucleoside triphosphate hydrolases;
sequence family	DNA replication factor Dna2;
redundant complexes	5eax_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5ean_A interface=126,154,158,391,393,452,513,563,673,700,740,790,792,990,996, gghmepldeldlllleavprvellrkkadalfpetvlsrgvdnrylvlavetsqnergaeekrlhvtasqdrehevlcilrngwssvpvepgdivhlegdctsepwiidddfgyfilypdmmisgTsvassirclrravlsetfrgsdpatrqMligTilhevfqkaisesfaperlqelalqtlrevrhlkemyrlnlsqdeilceveeylpsfskwaedfmrkgpssefpqmqlslpsdgrsspcnievvksldieesiwsprfglkgkidvtvgvkihrdckmkykvmplelktgkesnsiehrsqvvlytllsqerredpeagwllylktgqmypvpanhldkrellklrnwlaasllhrvsraapgeearlsalpqiieeektckYcSqigncalysraveeqgddasipeamlskiqeetrhlqlahlkyfslwclmltlesqskDnrkthqsiwltpaseleesgncvgnlvrtepvsrvcdgqylhnfqrkngpmpatnlmagdRiilsgeerklfalskgyvkkmnkaavtclldrnlstlpattvfrldreeRhgdistplgnlsklmestdpskrlreliidfrepqfiaylssvlphdakdtvanilkglnkpqrqamkrvllskdytlivgmpgtgkttticalvrilsacgfsvlltsYthsavdnillklakfkvgflrlgqshKvhpdiqkfteeeicrsrsiaslahleelynshpivattcMginhpifsrktfdfcivdeasqisqpvclgplffsrrfvlvgdhqqlppLvVnrearalgmseslfkrlernesavvqltvqyrmnrkimslsnkltyagklecgsdrvanavlalpnlkdarlslqlyadysdspwlagvlepdnpvcflntdkvpapeqvenggvsnvtearlivfltstfikagcspsdigviapyrqqlriisdllarssvgmvevntvdkyqgrdkslilvsfvrsnedgtlgeLlkdwrRlnvaltrakhklillgsvsslkrfpplgtlfdhlnaeqlildlpsreheslshil
interface signature	TMTYSDRRYKMLVLR

Estimated binding specificities ?

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# IC=8.808 IC/col=0.678 n_of_columns=13

specificity:

A |   0   0   0   9   0  24  24  24  21  96   0  19  60
C |   0  96   0   9  96  24  24  24  21   0   0  20  12
G |   0   0   0  67   0  24  24  24  33   0  96  38  12
T |  96   0  96  11   0  24  24  24  21   0   0  19  12

scan!

Dendrogram of similar interfaces ?

matrix format

  
  --------------QT--YTDT----RT                    +------------------4n0o_E    
                                       +----------1 
  ----------FARA--KC----------       +-2          +------------------7aud_E    
                                     ! ! 
  --------------------HTPTVT--     --3 +-----------------------------6sjf_D    
                                     ! 
  NCICNARGRG------------------   L   +-----------------------------4xrm_B

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updated Fri Sep 13 19:29:33 2024