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structure nameHOMODIMER OF TALE TYPE HOMEOBOX TRANSCRIPTION FACTOR MEIS1 COMPLEXES WITH SPECIFIC DNA
(Homeobox protein Meis2)
referenceMorgunova et al. Nature 527 384 2015
sourceHomo sapiens
experimentX-ray (resolution=1.60, R-factor=0.177)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain 28;
multimeric complexes4xrm_AB 4xrs_BI 5eg0_AB 5ego_AB
redundant complexes5bng_B 5eg0_A 4xrs 5ego
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNINRR

Estimated binding specificities ?

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# IC=5.339 IC/col=0.890 n_of_columns=6 specificity:   
A |   9   0  96   0  67  69
C |   9   0   0  96  11   9
G |  11  96   0   0   9   9
T |  67   0   0   0   9   9
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: MEIS1
TGACAGPubMed4xrm_B(8.80e-07), 4xrm_AB(1.60e-04), 5eg0_AB(2.61e-04), ... (total=5)
CCAATPubMed4xrm_AB(7.13e-03)
TGATTGACPubMed4xrm_B(6.36e-03)

Dendrogram of similar interfaces ?

matrix format
  
  RT--------ITQCNAMC--   L     +-----------------------------2r5y_A    
                             +-2 
  ----------VA--NAQART   L   ! !                           +-1o4x_A    
                           --3 +---------------------------1 
  ----------VTCCNAQART   L   !                             +-8g87_X    
                             ! 
  --DTRTRGTTKT--------   L   +-----------------------------2o8k_A    
                           

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updated Fri Sep 13 18:58:45 2024