4xrm_B : 3D-footprint complex

structure name	HOMODIMER OF TALE TYPE HOMEOBOX TRANSCRIPTION FACTOR MEIS1 COMPLEXES WITH SPECIFIC DNA (Homeobox protein Meis2)
reference	Morgunova et al. Nature 527 384 2015
source	Homo sapiens
experiment	X-ray (resolution=1.60, R-factor=0.177)
structural superfamily	Homeodomain-like;
sequence family	Homeobox domain 28;
multimeric complexes	4xrm_AB 4xrs_BI 5eg0_AB 5ego_AB
redundant complexes	5bng_B 5eg0_A 4xrs 5ego
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 4xrm_B interface=47,50,51,54,55, smgifpkvatnimrawlfqhlthpypseeqkkqlaqdtgltilqvnNwfINarRRivqpmidqs
interface signature	NINRR

Estimated binding specificities ?

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# IC=5.300 IC/col=0.883 n_of_columns=6

specificity:

A |   9   0  96   0  67  67
C |  11   0   0  96   9  11
G |   9  96   0   0  11   9
T |  67   0   0   0   9   9

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: MEIS1
TGACAG	PubMed	4xrm_B(8.80e-07), 4xrm_AB(1.60e-04), 5eg0_AB(2.61e-04), ... (total=5)
CCAAT	PubMed	4xrm_AB(7.13e-03)
TGATTGAC	PubMed	4xrm_B(6.36e-03)

Dendrogram of similar interfaces ?

matrix format

  
  RT--------ITQCNAMC--   L     +-----------------------------2r5y_A    
                             +-2 
  ----------VA--NAQART   L   ! !                           +-1o4x_A    
                           --3 +---------------------------1 
  ----------VTCCNAQART   L   !                             +-8g87_X    
                             ! 
  --DTRTRGTTKT--------   L   +-----------------------------2o8k_A

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updated Sun Aug 3 08:38:37 2025