interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF NKX2-5 AND TBX5 BOUND TO THE NPPA PROMOTER REGION
(HOMEOBOX PROTEIN NKX-2.5, T-BOX TRANSCRIPTION FACTOR TBX5)
referenceStirnimann et al. 'Cell(Cambridge,Mass.)' 164 999 2016
sourceMUS MUSCULUS
experimentX-ray (resolution=3.00, R-factor=0.196)
structural superfamilyp53-like transcription factors;Homeodomain-like;
sequence familyTbox; Homeobox domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRIQNYKRTFF

Estimated binding specificities ?

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# IC=11.161 IC/col=0.797 n_of_columns=14 specificity:   
A |   0  81  13  24  24   0   0   0  79  96   0  24   0  12
C |  96   5  67  24  24   7   0   0   5   0   0  24   0  11
G |   0   5   5  24  24   5   0  96   7   0  96  24  96  62
T |   0   5  11  24  24  84  96   0   5   0   0  24   0  11
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --------------RGTTATFGFG       +-----------------------------4a04_B    
                                 ! 
  RTQTVAQTNA--------------   L   !                              +8osb_E    
                               --5              +---------------1 
  RT--VTKGNAKA------------   L   !            +-3               +2lkx_A    
                                 !            ! ! 
  ----NCICNARGRG----------   L   +------------4 +---------------4xrm_B    
                                              ! 
  RT--IAQCNAMG------------   L                !           +----1b72_A    
                                              +-----------2 
  RC--IAQCNAYC------------   L                            +----3rkq_B    
                               

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updated Fri Sep 13 19:35:49 2024