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structure nameHOMO SAPIENS CCCTC-BINDING FACTOR (CTCF) ZNF4-7 AND DNA COMPLEX STRUCTURE
(Transcriptional repressor CTCF)
referenceHashimoto et al. 'Mol. 66 711 2017
sourceHomo sapiens
experimentX-ray (resolution=3.11, R-factor=0.239)
structural superfamilybeta-beta-alpha zinc fingers;
sequence familyZinc finger, C2H2 type;
reference complex5k5i_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureESKRDYKRQTRSDV

Estimated binding specificities ?

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# IC=12.323 IC/col=1.027 n_of_columns=12 specificity:   
A |   5   6   0   0   5   0   0   0   0   5   5  10
C |  80  10  96  96  90  96  96   0   0  81  65   5
G |   6  70   0   0   0   0   0   0  96   0   1  75
T |   5  10   0   0   1   0   0  96   0  10  25   6
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --ECSGKGRG--DGYCKGRG--QA----TC------RASCDCVT   L                      +-------5k5h_A    
                                                                   +----1 
  NGKTWTKG------HTHGRGTGTT--ACNA--KGRG--------   L     +-----------2    +-------1tf3_A    
                                                       !           ! 
  ----------RGSTYGYC----QC--TGSTRGYT----------       +-3           +------------4is1_C    
                                                     ! ! 
  ------------QA--TCRG--RG--YCRT--------------   L --4 +------------------------7txc_E    
                                                     ! 
  ------------NTSTNAVT--QTSTSGKG--RG----------   L   +-------------------------6u9q_A    
                                                   

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updated Thu Sep 12 21:38:10 2024