5k5h_A : 3D-footprint complex

structure name	HOMO SAPIENS CCCTC-BINDING FACTOR (CTCF) ZNF4-7 AND DNA COMPLEX STRUCTURE (Transcriptional repressor CTCF)
reference	Hashimoto et al. 'Mol. 66 711 2017
source	Homo sapiens
experiment	X-ray (resolution=3.11, R-factor=0.239)
structural superfamily	beta-beta-alpha zinc fingers;
sequence family	Zinc finger, C2H2 type;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 5k5h_A interface=13,15,16,19,41,43,44,47,69,72,99,101,102,105, pfkcsmcdyasvEvSKlkRhirshtgerpfqcslcsyasrDtYKlkRhmrthsgekpyecyicharftQsgTmkmhilqkhtenvakfhcphcdtviaRkSDlgVhlrkqh
interface signature	ESKRDYKRQTRSDV

Estimated binding specificities ?

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# IC=12.184 IC/col=1.015 n_of_columns=12

specificity:

A |   0  21   6   5  96   0   0   0   0   0  10   5
C |  80  10  10  86   0   0   0   1   0   0  85   6
G |  10  60  75   0   0  96  96  90  96  96   1  80
T |   6   5   5   5   0   0   0   5   0   0   0   5

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Dendrogram of similar interfaces ?

matrix format

  
  --ECSGKGRG--DGYCKGRG--QA----TC------RASCDCVT   L                      +-------5k5h_A    
                                                                   +----1 
  NGKTWTKG------HTHGRGTGTT--ACNA--KGRG--------   L     +-----------2    +-------1tf3_A    
                                                       !           ! 
  ----------RGSTYGYC----QC--TGSTRGYT----------       +-3           +------------4is1_C    
                                                     ! ! 
  ------------QA--TCRG--RG--YCRT--------------   L --4 +------------------------7txc_E    
                                                     ! 
  ------------NTSTNAVT--QTSTSGKG--RG----------   L   +-------------------------6u9q_A

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updated Tue Dec 17 02:05:32 2024