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structure nameHOMO SAPIENS CCCTC-BINDING FACTOR (CTCF) ZNF4-7 AND DNA COMPLEX STRUCTURE
(Transcriptional repressor CTCF)
referenceHashimoto et al. 'Mol. 66 711 2017
sourceHomo sapiens
experimentX-ray (resolution=3.11, R-factor=0.239)
structural superfamilybeta-beta-alpha zinc fingers;
sequence familyZinc finger, C2H2 type;
reference complex5k5i_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureESKRDYKRQTRSDV

Estimated binding specificities ?

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# IC=12.347 IC/col=1.029 n_of_columns=12 specificity:   
A |   5  32   5   0  96   0   0   0   0   0   6  10
C |  74   0   5  91   0   0   0   0   0   0  80   7
G |   5  64  85   0   0  96  96  85  96  96   5  74
T |  12   0   1   5   0   0   0  11   0   0   5   5
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --ECSGKGRG--DGYCKGRG--QA----TC------RASCDCVT   L                      +-------5k5h_A    
                                                                   +----1 
  NGKTWTKG------HTHGRGTGTT--ACNA--KGRG--------   L     +-----------2    +-------1tf3_A    
                                                       !           ! 
  ----------RGSTYGYC----QC--TGSTRGYT----------       +-3           +------------4is1_C    
                                                     ! ! 
  ------------QA--TCRG--RG--YCRT--------------   L --4 +------------------------7txc_E    
                                                     ! 
  ------------NTSTNAVT--QTSTSGKG--RG----------   L   +-------------------------6u9q_A    
                                                   

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updated Sat Aug 2 09:05:10 2025