structure name | HIC2 ZINC FINGER DOMAIN IN COMPLEX WITH THE DNA BINDING MOTIF-2 OF THE BCL11A ENHANCER (Hypermethylated in cancer 2 protein) |
reference | Horton et al. Nat.Genet. 54 1417 2022 |
source | Homo sapiens |
experiment | X-ray (resolution=3.04, R-factor=0.193) |
structural superfamily | beta-beta-alpha zinc fingers; |
sequence family | Zinc finger, C2H2 type; |
links to other resources | NAKB PDIdb DNAproDB |
protein sequence | |
interface signature | QTRRYR |
Estimated binding specificities ?
readout + contact |
A | 15 0 0 11 75 C | 14 0 0 82 5 G | 15 96 96 3 8 T | 52 0 0 0 8scan! |
Dendrogram of similar interfaces ?
matrix formatRGSTDCHGTT--RG--DAEG--RG-- L +-----------------------------5kl3_A ! QAHTTT--QA--TTLAHGTCDTRG-- L ! +1g2d_F --5 +--------------1 RGSTDCHGTT--RG--DAEG--RG-- L ! ! +6b0o_A ! +-------3 EC--SCKGRG--LT--FCNA------ L ! ! ! +--------1ubd_C +------4 +-----2 ----HTHGRGTGTT--ACNA--KGRG L ! +--------1tf3_A ! --TCYCKARG--QA----TC------ +----------------------5yeg_A |
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updated Sat Sep 14 04:46:40 2024