7txc_E : 3D-footprint complex

structure name	HIC2 ZINC FINGER DOMAIN IN COMPLEX WITH THE DNA BINDING MOTIF-2 OF THE BCL11A ENHANCER (Hypermethylated in cancer 2 protein)
reference	Horton et al. Nat.Genet. 54 1417 2022
source	Homo sapiens
experiment	X-ray (resolution=3.04, R-factor=0.193)
structural superfamily	beta-beta-alpha zinc fingers;
sequence family	Zinc finger, C2H2 type;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7txc_E interface=43,46,49,71,73,74, srpfkcsvcektykdpatlrqhekthwltrpfpcnicgkmftQrgTmtRhmrshlglkpfacdecgmrftRqYRltehmrvhsg
interface signature	QTRRYR

Estimated binding specificities ?

readout + contact

# IC=4.302 IC/col=0.860 n_of_columns=5

specificity:

A |  15   0   0  11  75
C |  14   0   0  81   5
G |  15  96  96   4   8
T |  52   0   0   0   8

scan!

Dendrogram of similar interfaces ?

matrix format

  
  RGSTDCHGTT--RG--DAEG--RG--   L   +-----------------------------5kl3_A    
                                   ! 
  QAHTTT--QA--TTLAHGTCDTRG--   L   !                             +1g2d_F    
                                 --5              +--------------1 
  RGSTDCHGTT--RG--DAEG--RG--   L   !              !              +6b0o_A    
                                   !      +-------3 
  EC--SCKGRG--LT--FCNA------   L   !      !       !     +--------1ubd_C    
                                   +------4       +-----2 
  ----HTHGRGTGTT--ACNA--KGRG   L          !             +--------1tf3_A    
                                          ! 
  --TCYCKARG--QA----TC------              +----------------------5yeg_A

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updated Wed Dec 18 11:26:46 2024