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structure nameHIC2 ZINC FINGER DOMAIN IN COMPLEX WITH THE DNA BINDING MOTIF-2 OF THE BCL11A ENHANCER
(Hypermethylated in cancer 2 protein)
referenceHorton et al. Nat.Genet. 54 1417 2022
sourceHomo sapiens
experimentX-ray (resolution=3.04, R-factor=0.193)
structural superfamilybeta-beta-alpha zinc fingers;
sequence familyZinc finger, C2H2 type;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureQTRRYR

Estimated binding specificities ?

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# IC=4.334 IC/col=0.867 n_of_columns=5 specificity:   
A |  15   0   0  11  75
C |  14   0   0  82   5
G |  15  96  96   3   8
T |  52   0   0   0   8
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RGSTDCHGTT--RG--DAEG--RG--   L   +-----------------------------5kl3_A    
                                   ! 
  QAHTTT--QA--TTLAHGTCDTRG--   L   !                             +1g2d_F    
                                 --5              +--------------1 
  RGSTDCHGTT--RG--DAEG--RG--   L   !              !              +6b0o_A    
                                   !      +-------3 
  EC--SCKGRG--LT--FCNA------   L   !      !       !     +--------1ubd_C    
                                   +------4       +-----2 
  ----HTHGRGTGTT--ACNA--KGRG   L          !             +--------1tf3_A    
                                          ! 
  --TCYCKARG--QA----TC------              +----------------------5yeg_A    
                                 

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updated Sat Sep 14 04:46:40 2024