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structure nameX-RAY CRYSTAL STRUCTURE OF MARINITOGA PIEZOPHILA ARGONAUTE IN COMPLEX WITH 5' OH GUIDE RNA AND TARGET DNA
(Argonaute protein)
referenceDoxzen et al. 'PLoS 12 e0177097 2017
sourceMarinitoga piezophila
experimentX-ray (resolution=3.20, R-factor=0.218)
structural superfamilyRibonuclease H-like;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureKTKFFLYT

Estimated binding specificities ?

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# IC=7.740 IC/col=0.645 n_of_columns=12 specificity:   
A |   0  15  24  24  24   0  24   8   6  64   0   0
C |   0  13  24  24  24   0  24   6   6   6  96  96
G |  96   0  24  24  24   0  24  82   9  13   0   0
T |   0  68  24  24  24  96  24   0  75  13   0   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  KG--TT------------------------KCFC--------------------------FALG--YCTC--   L                         +-----------5ux0_A    
                                                                                               +-------2 
  --TGRA--KTQTKT--------NCYC--TG--LTYTYGHTNG--------RA----NT----------KA--   L                 !       !  +--------6qzk_A    
                                                                                               !       +--1 
  ----LA--------PTMT--WT--RTITNT--HCRG--NG------------------DGRG--RGFGAGFG                     !          +--------4n41_B    
                                                                                     +---------5 
  ----KGYARC--------------------SA--YA--------RT--RC------DCRA----SA--LAPA   L       !         !   +----------------6d92_F    
                                                                                     !         ! +-3 
  ------------------YA--------RA----FAYTDTNT------------------------FTRA--         +-6         +-4 +----------------6t5t_A    
                                                                                   ! !           ! 
  --------------------------NT--------------------------------------------         ! !           +------------------5g5t_A    
                                                                                 +-7 ! 
  ----------------------------------------------NG------------------------       ! ! +-----------------------------4h8k_A    
                                                                               --8 ! 
  ------------------------------------------NTRG--------------------------   L   ! +-----------------------------2qkb_A    
                                                                                 ! 
  ----------------------------------------------------QGTG----------------       +-----------------------------6dop_A    
                                                                               

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updated Fri Sep 13 20:33:50 2024