interface graph thumbnail
legend  pdf

structure nameMOUSEZFP568-ZNF2-11 IN COMPLEX WITH DNA
(Zinc finger protein 568)
referencePatel et al. Cell 173 221 2018
sourceMus musculus
experimentX-ray (resolution=2.79, R-factor=0.196)
structural superfamilybeta-beta-alpha zinc fingers;
sequence familyZinc finger, C2H2 type;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRSHRYDTCSLISSHRRERCTERRERSERRHQ

Estimated binding specificities ?

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# IC=25.637 IC/col=1.068 n_of_columns=24 specificity:   
A |   0   0   0   0  10  24   0   8  96   0   0   0   0  13   0   0   0  96   0   2  69   0   0  90
C |  96  96  96   0   8  24   0  13   0  96  96  56   0  12   0  96  96   0  96   5  19  96  96   2
G |   0   0   0   0  15  24   0   8   0   0   0   1  96   8  96   0   0   0   0  85   2   0   0   2
T |   0   0   0  96  63  24  96  67   0   0   0  39   0  63   0   0   0   0   0   4   6   0   0   2
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RGSGHGRGYADCTACTST--LTITSTSTHTRG----RG--ECRA--TGECRGRG----ETRG--SAECRG--RGHGQT   L              +---------------5wjq_D    
                                                                                          +-------2 
  ------------------LA----TT--ECRGYG--EC----RG--YCKGRGQA----TC----SC------------   L   +--3       +---------------8sst_A    
                                                                                       !  ! 
  ----------------------------------QT----KGRGRGDCKG----------RGSTDCHG--RG------   L --4  +-----------------------8e3e_F    
                                                                                       ! 
  --------------------------------------SGHG--RGDAETRGRG--DCHG------------------   L   !                       +--6vtx_A    
                                                                                       +-----------------------1 
  --------------------------------------TTSGRG--QCYC--NTYGQGFT------------------   L                           +--5vmz_A    
                                                                                     

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updated Sat Jan 10 09:19:17 2026