6vtx_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF HUMAN KLF4 ZINC FINGER DNA BINDING DOMAIN IN COMPLEX WITH NANOG DNA (Krueppel-like factor 4)
reference	Ferreon et al. 'Nat 12 5579 2021
source	Homo sapiens
experiment	X-ray (resolution=2.14, R-factor=0.218)
structural superfamily	beta-beta-alpha zinc fingers;
sequence family	Zinc finger, C2H2 type;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6vtx_A interface=16,17,44,46,47,50,72,74,75, htcdyagcgktytksSHlkahlrthtgekpyhcdwdgcgwkfaRsDEltRhyrkhtghrpfqcqkcdrafsRsDHlalhmkrh
interface signature	SHRDERRDH

Estimated binding specificities ?

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# IC=8.339 IC/col=1.042 n_of_columns=8

specificity:

A |  13   0   0   0   0   0  13   0
C |  13   0   0   0   0   0  16   0
G |  43  96  96  96   0  96  13  96
T |  27   0   0   0  96   0  54   0

scan!

Dendrogram of similar interfaces ?

matrix format

  
  --SGHG--RGDAETRGRG--DCHG--   L                    +6vtx_A    
                                            +-------1 
  RG--ECRA--TGECRGRG----ET--   L   +--------2       +5wjq_D    
                                   !        ! 
  EC----RG--YCKGRGQA----TC--   L --4        +-------8sst_A    
                                   ! 
  --TTSGRG--QCYC--NTYGQGFT--   L   !     +----------5vmz_A    
                                   +-----3 
  RGDCKG----------RGSTDCHGRG   L         +----------8e3e_F

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updated Sat Jan 10 12:24:32 2026