6vtx_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF HUMAN KLF4 ZINC FINGER DNA BINDING DOMAIN IN COMPLEX WITH NANOG DNA (Krueppel-like factor 4)
reference	Ferreon et al. 'Nat 12 5579 2021
source	Homo sapiens
experiment	X-ray (resolution=2.14, R-factor=0.218)
structural superfamily	beta-beta-alpha zinc fingers;
sequence family	Zinc finger, C2H2 type;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6vtx_A interface=16,17,44,46,47,50,72,74,75, htcdyagcgktytksSHlkahlrthtgekpyhcdwdgcgwkfaRsDEltRhyrkhtghrpfqcqkcdrafsRsDHlalhmkrh
interface signature	SHRDERRDH

Estimated binding specificities ?

readout + contact

# IC=8.431 IC/col=1.054 n_of_columns=8

specificity:

A |   0  54   0  96   0   0   0  13
C |  96  13  96   0  96  96  96  54
G |   0  13   0   0   0   0   0  13
T |   0  16   0   0   0   0   0  16

scan!

Dendrogram of similar interfaces ?

matrix format

  
  --SGHG--RGDAETRGRG--DCHG   L                    +6vtx_A    
                                           +------1 
  RG--ECRA--TGECRGRG----ET   L   +---------2      +5wjq_D    
                                 !         ! 
  EC----RG--YCKGRGQA----TC   L --3         +-------8sst_A    
                                 ! 
  --TTSGRG--QCYC--NTYGQGFT   L   +-----------------5vmz_A

home
updated Tue Jun 30 01:57:07 2026