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legend  pdf

structure nameCRYSTAL STRUCTURE OF THE DOUBLE HOMEODOMAIN OF DUX4 IN COMPLEX WITH A DNA APTAMER
(Double homeobox protein 4)
referenceAihara et al. 'Faseb 34 4573 2020
sourceHomo sapiens
experimentX-ray (resolution=2.34, R-factor=0.218)
structural superfamilyHomeodomain-like;
sequence familyHomeobox domain;
redundant complexes6u82
reference complex5zfz_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureQSRRIQNR

Estimated binding specificities ?

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# IC=3.880 IC/col=0.776 n_of_columns=5 specificity:   
A |  16   2   0  95  11
C |  16  11   0   0  10
G |  19   3  96   1  11
T |  45  80   0   0  64
scan!

Dendrogram of similar interfaces ?

matrix format
  
  RA--RT--ITQTNASGRARCRARTITQTNARG   L            +----------------6u81_A    
                                           +------1 
  --RCRT--NT--NAITRG--------------       +-2      +----------------5zjt_B    
                                         ! ! 
  ----RA--YAQTNAAARG--------------   L --3 +-----------------------6wig_A    
                                         ! 
  ------RTVAITNAMCRG--------------   L   +-------------------------1yrn_A    
                                       

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updated Fri Sep 13 02:18:56 2024