6u81_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF THE DOUBLE HOMEODOMAIN OF DUX4 IN COMPLEX WITH A DNA APTAMER (Double homeobox protein 4)
reference	Aihara et al. 'Faseb 34 4573 2020
source	Homo sapiens
experiment	X-ray (resolution=2.34, R-factor=0.218)
structural superfamily	Homeodomain-like;
sequence family	Homeobox domain;
multimeric complexes	5z2t_CD 6dfy_CD
redundant complexes	6u82
reference complex	6a8r_A
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 6u81_A interface=50,54,77,80,122,125,126,130, grrrrlvwtpsqsealracfernpypgiatrerlaqaigipeprvqiwfQnerSrqlrqhrresrpwpgrrgppegRrkRtavtgsqtalllrafekdrfpgiaareelaretglpesriqIwfQNrraRhp
interface signature	QSRRIQNR

Estimated binding specificities ?

readout + contact

# IC=3.918 IC/col=0.784 n_of_columns=5

specificity:

A |  16   2   0  95  11
C |  16  10   0   0  10
G |  19   2  96   1  12
T |  45  82   0   0  63

scan!

Dendrogram of similar interfaces ?

matrix format

  
  RA--RT--ITQTNASGRARCRARTITQTNARG   L            +----------------6u81_A    
                                           +------1 
  --RCRT--NT--NAITRG--------------       +-2      +----------------5zjt_B    
                                         ! ! 
  ----RA--YAQTNAAARG--------------   L --3 +-----------------------6wig_A    
                                         ! 
  ------RTVAITNAMCRG--------------   L   +-------------------------1yrn_A

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updated Fri Jan 9 10:21:02 2026