7eyi_G : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF ZBTB7A IN COMPLEX WITH GAMMA-GLOBIN -200 SEQUENCE ELEMENT WITH C-194A MUTATION (Zinc finger and BTB domain-containing protein 7A)
reference	Shi et al. 'Cell 36 109759 2021
source	Homo sapiens
experiment	X-ray (resolution=2.40, R-factor=0.224)
structural superfamily	beta-beta-alpha zinc fingers;
sequence family	Zinc finger, C2H2 type;
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7eyi_G interface=15,17,20,42,44,45,72,98,99,100,101,104, hmqkcpicekviqgAgKlpRhirthtgekpyecnickvrftRqDKlkvhmrkhtgekpylcqqcgaafahnYdlknhmrvhtglrpyqcdsccktfvRSDHlhRhlkkdgc
interface signature	AKRRDKYRSDHR

Estimated binding specificities ?

readout + contact

# IC=7.754 IC/col=0.775 n_of_columns=10

specificity:

A |   8   1   0   1  22  19  11   2   0  79
C |  68  95  95  94  22  19  62  91  95   5
G |  10   0   0   1  22  18  11   2   0   6
T |  10   0   1   0  30  40  12   1   1   6

scan!

Dendrogram of similar interfaces ?

matrix format

  
  --AG--KG--RG--RGDCKG--------YC------RGSTDCHG--RG   L                           +7eyi_G    
                                                                +----------------1 
  TTSC--EC--RGYGECSCKGRG--DG--YCKGRGTCQA----TC----   L          !                +5t0u_A    
                                                             +--3 
  ----QARA--VT--TT--NA----ECYTSGSTKG--QA----SA----   L       !  !    +------------6wmi_A    
                                                         +---4  +----2 
  ------------------YG----WT--WTSTET--FTVASGDCSART   L   !   !       +------------6a57_A    
                                                       --5   ! 
  ----TTSGRTRG--LTECYC----NTYGQGFT----------------   L   !   +--------------------2lt7_A    
                                                         ! 
  ----SA--------TT--NAVTRT------------------------       +------------------------7y3m_I

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updated Tue Dec 19 18:17:54 2023