7n2m_A : 3D-footprint complex

structure name	CRYSTAL STRUCTURE OF DNA POLYMERASE ALPHA CATALYTIC CORE IN COMPLEX WITH DCTP AND TEMPLATE/PRIMER HAVING T-C MISMATCH AT THE POST- INSERTION SITE (DNA POLYMERASE ALPHA CATALYTIC SUBUNIT)
reference	Baranovskiy et al. Proc.Natl.Acad.Sci.USA 119 e2111744119 2022
source	HOMO SAPIENS
experiment	X-ray (resolution=2.90, R-factor=?)
structural superfamily	DNA/RNA polymerases;Ribonuclease H-like;
sequence family	DNA polymerase family B; DNA polymerase family B, exonuclease do;
multimeric complexes	8d0b_ABF
reference complex	8d0b_F
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7n2m_A interface=443,468,499,572,575,576,578,583,585,674, eqvfhfywldayedqynqpgvvflfgkvwiesaethvsccvmvkniertlyflpremkidlntgketgtpismkdvyeefdekiatkykimkfkskpveknyafeipdvpekseylevkysaempqlpqdlkgetfshvfgtntsslelflmnrkikgpcwlevkspqllnqpvswckaeamalkpdlvnvikdvsppplvvmafsmktmqnaknhqneiiamaalvhhsfaldkaapkppfqshfcvvskpkdcifpyafkeviekknvkvevaatertllgfflakvhkidpdiivghniygfelevllqrinvckaphwskigrlkrsnmpklgfgernatcgrmicdveisakelircksyhlselvqqilktervvipmeniqnmysessqllyllehtwkdakfilqimcelnvlplalqitniagnimsrtlmggRserneflllhafyennyivpdkqiRkkaayagglvldpkvgfydkfillldfnslYpsiiqefnicfttvqrveqipelpdpslemgilpreirklverrkqvkqlmkqqdlnpdlilqydirqkalkLtaNSmYgclgFsYsrfyakplaalvtykgreilmhtkemvqkmnleviygdtdsimintnstnleevfklgnkvksevnklyklleididgvfksllllkkKkyaalvveptsdgnyvtkqelkgldivrrdwcdlakdtgnfvigqilsdqsrdtiveniqkrlieigenvlngsvpvsqfeinkaltkdpqdypdkkslphvhvalwinsqggrkvkagdtvsyvicqdgsnltasqrayapeqlqkqdnltidtqyylaqqihpvvaricepidgidavliatwlgldpt
interface signature	RRYLNSYFYK

Estimated binding specificities ?

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# IC=5.546 IC/col=1.109 n_of_columns=5

specificity:

A |  96   0  14   0   0
C |   0   0  14  96   0
G |   0  96  14   0  96
T |   0   0  54   0   0

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updated Sat Aug 2 17:24:53 2025