interface graph thumbnail
legend  pdf

structure nameSTRUCTURE OF FOXP3-DNA COMPLEX
referenceLeng et al. Immunity 55 1354 2022
experimentX-ray (resolution=4.00, R-factor=0.336)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyFork head domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNRHS

Estimated binding specificities ?

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# IC=5.175 IC/col=0.863 n_of_columns=6 specificity:   
A |   0  36  96  96  20  96
C |   5  25   0   0  45   0
G |   5  20   0   0  25   0
T |  86  15   0   0   6   0
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --------NASTRGHT--STLT--------   L                          +------7cby_C    
                                                           +--1 
  --ST----NASTRTHT--ST----------   L               +-------2  +------3l2c_A    
                                                   !       ! 
  ------RTSTHG------------RA----   L   +-----------3       +---------3zpl_B    
                                       !           ! 
  TT--KATTQTTG--LTRT----KA--FTYT   L --4           +-----------------2p7c_B    
                                       ! 
  --------------YG--------------       +-----------------------------3eyi_B    
                                     

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updated Fri Jan 9 17:49:02 2026