interface graph thumbnail
legend  pdf

structure nameCRYSTAL STRUCTURE OF THE DNA BINDING DOMAIN OF FOXO4 BOUND TO DNA
(Forkhead box protein O4)
referenceObsilova et al. 'Acta 66 1351 2010
sourceHomo sapiens
experimentX-ray (resolution=1.87, R-factor=0.195)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyFork head domain;
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureSNSRHS

Estimated binding specificities ?

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# IC=6.184 IC/col=0.883 n_of_columns=7 specificity:   
A |   6   0  90  96  76   8  76
C |  70   0   0   0   6  76   6
G |   8   0   6   0   6   6   6
T |  12  96   0   0   8   6   8
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: FOXO4
TTGTTTACPubMed3l2c_A(1.35e-11)

Dendrogram of similar interfaces ?

matrix format
  
  ------ST------NASTRTHT--ST------   L                    +---3l2c_A    
                                                    +-----1 
  --------------NASTRGHT--STLT----   L       +------2     +---7cby_C    
                                             !      ! 
  ------------RTSTHG------------RA   L   +---3      +---------3zpl_B    
                                         !   ! 
  RT--LA--HGTTETYTRG--------------   L --4   +----------------1f4k_B    
                                         ! 
  --TT------KATTQTTG--LTRT----KA--   L   +--------------------2p7c_B    
                                       

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updated Fri Sep 13 17:23:25 2024