7vox_H : 3D-footprint complex

structure name	THE CRYSTAL STRUCTURE OF HUMAN FORKHEAD BOX PROTEIN A IN COMPLEX WITH DNA 2 (Hepatocyte nuclear factor 3-alpha)
reference	Yoon et al. 'Nucleic 50 8929 2022
source	Homo sapiens
experiment	X-ray (resolution=2.10, R-factor=0.187)
structural superfamily	"Winged helix" DNA-binding domain;
sequence family	Fork head domain;
multimeric complexes	7vox_CH
redundant complexes	1vtn_C
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 7vox_H interface=46,49,50,52,53,56,57,73, hakppysyislitmaiqqapskmltlseiyqwimdlfpyyrqnqqRwqNSiRHslSFndcfvkvarspdkpgKgsywtlhpdsgn
interface signature	RNSRHSFK

Estimated binding specificities ?

readout + contact

# IC=5.100 IC/col=0.638 n_of_columns=8

specificity:

A |  62  24  11  24   0   0   8  69
C |  17  24   8  24   0   0   0   8
G |  17  24   8  24   0   0   1   8
T |   0  24  69  24  96  96  87  11

scan!

Dendrogram of similar interfaces ?

matrix format

  
  --------------NASTRGHT--STLT----   L                +-------7cby_C    
                                                    +-1 
  ----ST--------NASTRTHT--ST------   L       +------2 +-------3l2c_A    
                                             !      ! 
  --------RGSTRTSTHG------------RA   L   +---3      +---------3zpl_B    
                                         !   ! 
  --LA--NTHGTTETYTRG--------------   L --4   +----------------1f4k_B    
                                         ! 
  TT--------KATTQTTG--LTRT----KA--   L   +--------------------2p7c_B

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updated Sat Sep 14 06:45:05 2024