interface graph thumbnail
legend  pdf

structure nameTHE CRYSTAL STRUCTURE OF HUMAN FORKHEAD BOX PROTEIN A IN COMPLEX WITH DNA 2
(Hepatocyte nuclear factor 3-alpha)
referenceYoon et al. 'Nucleic 50 8929 2022
sourceHomo sapiens
experimentX-ray (resolution=2.10, R-factor=0.187)
structural superfamily"Winged helix" DNA-binding domain;
sequence familyFork head domain;
multimeric complexes7vox_CH
redundant complexes1vtn_C
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRNSRHSFK

Estimated binding specificities ?

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# IC=4.250 IC/col=0.708 n_of_columns=6 specificity:   
A |  12  84  96  96  24  60
C |  12   0   0   0  24  12
G |  12  12   0   0  24  12
T |  60   0   0   0  24  12
scan!

Dendrogram of similar interfaces ?

matrix format
  
  --------------NASTRGHT--STLT----   L                     +------7cby_C    
                                               +-----------1 
  ----ST--------NASTRTHT--ST------   L     +---2           +------3l2c_A    
                                           !   ! 
  --LA--NTHGTTETYTRG--------------   L   +-3   +------------------1f4k_B    
                                         ! ! 
  --------RGSTRTSTHG------------RA   L --4 +----------------------3zpl_B    
                                         ! 
  TT--------KATTQTTG--LTRT----KA--   L   +------------------------2p7c_B

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updated Wed Dec 18 13:35:17 2024