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structure namePHOSPHATE SYSTEM POSITIVE REGULATORY PROTEIN PHO4/DNA COMPLEX
(PROTEIN PHOSPHATE SYSTEM POSITIVE REGULATORY PROTEIN PHO4)
referenceHakoshima et al. 'EMBO 16 4689 1997
sourceSaccharomyces cerevisiae
experimentX-ray (resolution=2.80, R-factor=?)
structural superfamilyHLH, helix-loop-helix DNA-binding domain;
sequence familyHelixloophelix DNAbinding domain;
multimeric complexes1a0a_AB
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureRHKERR

Estimated binding specificities ?

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# IC=4.475 IC/col=0.895 n_of_columns=5 specificity:   
A |  13  13   0   0   0
C |  54  13   0   0   0
G |  16  57   0  96  96
T |  13  13  96   0   0
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: PHO4
CACGTGPubMed1a0a_B(3.54e-04), 1a0a_AB(1.14e-09)
NNCACGTGNNPubMed1a0a_B(4.06e-03), 1a0a_AB(1.48e-06)
CACGTPubMed1a0a_B(1.34e-04), 1a0a_AB(9.23e-07)
GCACGTGGGPubMed1a0a_B(3.60e-06), 1a0a_AB(1.05e-10)
GCACGTTTTPubMed1a0a_B(2.91e-03), 1a0a_AB(4.54e-04)
CANNTGPubMed1a0a_AB(3.94e-03)

Dendrogram of similar interfaces ?

matrix format
  
  RG--HGKT--EARCRC--   L                          +--1a0a_B    
                                          +-------1 
  ----HGNT--ECRCRG--   L        +---------2       +--7d8t_A    
                                !         ! 
  ----HGNTMTEARCRG--         +--3         +----------1nlw_D    
                             !  ! 
  ----HG----ETRTRG--       +-4  +--------------------5v0l_A    
                           ! ! 
  ----HG----ETRCRG--   L --5 +-----------------------5gnj_I    
                           ! 
  --QG----VTECRCRGQG   L   +------------------------1an4_A

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updated Fri Sep 13 15:21:47 2024