1am9_A : 3D-footprint complex

structure name	HUMAN SREBP-1A BOUND TO LDL RECEPTOR PROMOTER (PROTEIN STEROL REGULATORY ELEMENT BINDING PROTEIN 1A)
reference	Burley et al. Structure 6 661 1998
source	Homo sapiens
experiment	X-ray (resolution=2.30, R-factor=0.219)
structural superfamily	HLH, helix-loop-helix DNA-binding domain;
sequence family	Helixloophelix DNAbinding domain;
multimeric complexes	1am9_AB 1am9_CD
links to other resources	NAKB PDIdb DNAproDB
protein sequence	> 1am9_A interface=10,11,13,14,17,18, qsrgekrtaHNaIEkrYRssindkiielkdlvvgteaklnksavlrkaidyirflqhsnqklkqenlslrtavhkskslk
interface signature	HNIEYR

Estimated binding specificities ?

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# IC=5.707 IC/col=0.951 n_of_columns=6

specificity:

A |  13   0   0   0  96  13
C |  29   0   0   0   0  57
G |  41  96   0  96   0  13
T |  13   0  96   0   0  13

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Related DNA sequences reported in the literature ?

site	source	matches (E-value)
term: SREBP-1A
GTGGGCTGAG	PubMed	1am9_AB(4.60e-10), 1am9_CD(6.23e-09)
ATCACCGCATG	PubMed	1am9_A(1.20e-05), 1am9_AB(3.01e-06), 1am9_CD(1.57e-05)
ATCACCCCATG	PubMed	1am9_A(1.20e-05), 1am9_AB(1.10e-10), 1am9_CD(1.56e-09)

Dendrogram of similar interfaces ?

matrix format

  
  --HGNT--MTEA----RCRG------           +-----------------------------1nlw_D    
                                     +-2 
  --------HGNT----EC----RCRG   L     ! !        +--------------------7d8t_A    
                                   +-3 +--------1 
  NT--RGEC----RC------------       ! !          +--------------------2ql2_A    
                                 --4 ! 
  --------HG------ET----RCRG   L   ! +-----------------------------5gnj_I    
                                   ! 
  ------HG------ET----RTRG--       +-----------------------------5v0l_A

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updated Fri Sep 13 15:23:06 2024