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structure nameCRYSTAL STRUCTURE OF THE LAC REPRESSOR DIMER BOUND TO OPERATOR AND THE ANTI-INDUCER ONPF
(LAC REPRESSOR)
referenceBell et al.
sourceEscherichia coli
experimentX-ray (resolution=2.60, R-factor=0.247)
structural superfamilyPeriplasmic binding protein-like I;lambda repressor-like DNA-binding domains;
sequence familyBacterial regulatory proteins, lacI fami; Periplasmic binding proteins and sugar b;
multimeric complexes1efa_AB 1jwl_AB 1lbg_AB 1lbg_CD 2pe5_AB
redundant complexes1jwl_B 1lbg_D 2pe5_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureLYSYQSRHALA

Estimated binding specificities ?

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# IC=8.957 IC/col=0.995 n_of_columns=9 specificity:   
A |   9   0   7   9   0  96   0  96  73
C |  73   0  75   7  96   0  96   0   7
G |   7  96   7   7   0   0   0   0   9
T |   7   0   7  73   0   0   0   0   7
scan!

Dendrogram of similar interfaces ?

matrix format
  
  LTYCSGYGQC--STRG--HT--AG--LGAC   L                              +1efa_B    
                                                        +---------2 
  ITYTSGMTAA--STRG--NT--AG--LCAT   L                    !         ! +3oqm_C    
                                                  +-----3         +-1 
  IT--ST--ATTTSTRG----VTAG--LCAC                  !     !           +1rzr_C    
                                       +----------4     ! 
  ----SG--TC------RG--------LCKA   L   !          !     +----------1jft_A    
                                     --5          ! 
  LT----ITTGTTST----DCIT--LCRT--   L   !          +----------------7ce1_D    
                                       ! 
  --YT--YTQATTSTRT--HG------RT--       +---------------------------1osl_A    
                                     

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updated Fri Sep 13 15:32:22 2024