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structure nameTHE 3D STRUCTURE OF THE HUMAN SRY-DNA COMPLEX SOLVED BY MULTI- DIMENSIONAL HETERONUCLEAR-EDITED AND-FILTERED NMR
experimentNMR
structural superfamilyHMG-box;
sequence familyHMG high mobility group box;
redundant complexes1hry
reference complex1hry_A
links to other resourcesNAKB PDBSum PDIdb DNAproDB
protein sequence
interface signatureNFIRRSISY

Estimated binding specificities ?

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# IC=5.766 IC/col=0.961 n_of_columns=6 specificity:   
A |  13  13   0   0   0   0
C |  16  16   0   0   0   0
G |  54  13   0   0  96   0
T |  13  54  96  96   0  96
scan!

Related DNA sequences reported in the literature ?


sitesourcematches (E-value)
term: SRY
AACAATPubMed1hrz_A(1.12e-03), 1hry_A(1.12e-03)
AACAAAGPubMed1hrz_A(6.36e-06), 1hry_A(6.24e-06)
TCAAAGPubMed1hrz_A(1.13e-03), 1hry_A(1.12e-03)
GAACAATPubMed1hrz_A(3.37e-03), 1hry_A(3.37e-03)
CTTTGPubMed1hrz_A(3.59e-04), 1hry_A(3.54e-04)
ATTGTTPubMed1hrz_A(1.12e-03), 1hry_A(1.12e-03)
NACAATPubMed1hrz_A(1.12e-03), 1hry_A(1.12e-03)
ACAATPubMed1hrz_A(3.54e-04), 1hry_A(3.54e-04)

Dendrogram of similar interfaces ?

matrix format
  
  RCNAFTIA--RG--NC----SA--LT----YA   L   +--------------------------2gzk_A    
                                         ! 
  RGNTFTMA--RT----RT--SA--------WA   L --4             +------------7m5w_A    
                                         !   +---------2 
  RCNTFTMA--RAHG------SA--------YA   L   !   !         +------------3f27_D    
                                         +---3 
  RC--YTMALTRA----TG--AA----VCEC--   L       !             +--------1qrv_A    
                                             +-------------1 
  ----YA------------FT--SG--------                         +--------5ze0_N

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updated Sat Aug 2 00:57:31 2025